Sex-specific regulation of aging in Caenorhabditis elegans

Aging Cell
Bernadette HotziTibor Vellai

Abstract

A fascinating aspect of sexual dimorphism in various animal species is that the two sexes differ substantially in lifespan. In humans, for example, women's life expectancy exceeds that of men by 3-7 years. Whether this trait can be attributed to dissimilar lifestyles or genetic (regulatory) factors remains to be elucidated. Herein, we demonstrate that in the nematode Caenorhabditis elegans, the significantly longer lifespan of hermaphrodites-which are essentially females capable of sperm production-over males is established by TRA-1, the terminal effector of the sex-determination pathway. This transcription factor directly controls the expression of daf-16/FOXO, which functions as a major target of insulin/IGF-1 signaling (IIS) and key modulator of aging across diverse animal phyla. TRA-1 extends hermaphrodite lifespan through promoting daf-16 activity. Furthermore, TRA-1 also influences reproductive growth in a DAF-16-dependent manner. Thus, the sex-determination machinery is an important regulator of IIS in this organism. These findings provide a mechanistic insight into how longevity and development are specified unequally in the two genders. As TRA-1 is orthologous to mammalian GLI (glioma-associated) proteins, a similar se...Continue Reading

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Citations

Mar 24, 2020·Redox Biology·John TowerKelvin J A Davies
Sep 18, 2021·G3 : Genes - Genomes - Genetics·Cori K Cahoon, Diana E Libuda
Dec 21, 2021·Frontiers in Cell and Developmental Biology·Huihui JiIngrid Herr

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Methods Mentioned

BETA
immunoprecipitation
transgenic
confocal microscopy
ChIP
PCR
electrophoresis

Software Mentioned

REST
SPSS17
SPSS
BiSearch

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