Sex-Specific Response of Caenorhabditis elegans to Methylmercury Toxicity

Neurotoxicity Research
Joanna A RuszkiewiczMichael Aschner

Abstract

Methylmercury (MeHg), an abundant environmental pollutant, has long been known to adversely affect neurodevelopment in both animals and humans. Several reports from epidemiological studies, as well as experimental data indicate sex-specific susceptibility to this neurotoxicant; however, the molecular bases of this process are still not clear. In the present study, we used Caenorhabditis elegans (C. elegans), to investigate sex differences in response to MeHg toxicity during development. Worms at different developmental stage (L1, L4, and adult) were treated with MeHg for 1 h. Lethality assays revealed that male worms exhibited significantly higher resistance to MeHg than hermaphrodites, when at L4 stage or adults. However, the number of worms with degenerated neurons was unaffected by MeHg, both in males and hermaphrodites. Lower susceptibility of males was not related to changes in mercury (Hg) accumulation, which was analogous for both wild-type (wt) and male-rich him-8 strain. Total glutathione (GSH) levels decreased upon MeHg in him-8, but not in wt. Moreover, the sex-dependent response of the cytoplasmic thioredoxin system was observed-males exhibited significantly higher expression of thioredoxin TRX-1, and thioredoxin re...Continue Reading

References

Mar 2, 1999·Developmental Biology·C Q NguyenD H Fitch
Dec 6, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Changhoon JeeJoohong Ahnn
Apr 24, 2007·Neurotoxicity Research·Carolina JohanssonSandra Ceccatelli
Apr 4, 2009·Toxicology and Applied Pharmacology·Kirsten J HelmckeMichael Aschner
Nov 27, 2009·Stroke; a Journal of Cerebral Circulation·Tzu-Yin ChenChin Hsu
Aug 10, 2010·Toxicology and Applied Pharmacology·Kirsten J Helmcke, Michael Aschner
Dec 15, 2010·Human & Experimental Toxicology·Daiana AvilaMichael Aschner
Feb 22, 2011·Biochemical and Biophysical Research Communications·Juan Carlos Fierro-GonzálezPeter Swoboda
Jun 21, 2011·Life Sciences·Marcelo FarinaMichael Aschner
May 2, 2013·Toxicology·Sabrina LlopFerran Ballester
Oct 15, 2013·BMC Genomics·Matthew K McElweeJonathan H Freedman
Nov 7, 2013·Neurochemical Research·Ebany J Martinez-FinleyMichael Aschner
Nov 27, 2014·Archives of Environmental Contamination and Toxicology·Rejane C MarquesJosé G Dórea
Aug 13, 2015·Metallomics : Integrated Biometal Science·Hanna LohrenTanja Schwerdtle
Aug 27, 2015·Current Protocols in Toxicology·Samuel W Caito, Michael Aschner
Mar 19, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alessandra Antunes Dos SantosMichael Aschner
Oct 28, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Martina RudgalvyteGarry Wong
Sep 11, 2017·Advances in Neurobiology·Marcelo Farina, Michael Aschner
Mar 20, 2018·Toxicology and Applied Pharmacology·Joanna A RuszkiewiczMichael Aschner
Mar 22, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Yuet-Kin LeungShuk-Mei Ho

❮ Previous
Next ❯

Citations

Feb 3, 2020·Chemico-biological Interactions·Blessing A AfolabiAna Lúcia Anversa Segatto
Sep 18, 2021·G3 : Genes - Genomes - Genetics·Cori K Cahoon, Diana E Libuda
Jan 7, 2022·Chemical Research in Toxicology·Jingjing PanWei Liu
Feb 27, 2021·Current Hypertension Reviews·Nzube F OlungOmamuyovwi M Ijomone

❮ Previous
Next ❯

Methods Mentioned

BETA
Protein Assay
transgenic

Software Mentioned

Image
Volocity
Prism
SPSS
GraphPad

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.