Sex-specific role of thioredoxin in neuroprotection against iron-induced brain injury conferred by estradiol.

Stroke; a Journal of Cerebral Circulation
Tzu-Yin ChenChin Hsu

Abstract

Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo. Age-matched male and female Sprague-Dawley rats were stereotaxically infused with either ferrous citrate (FC) or saline (10 muL) into the right caudate nucleus. Beta-estradiol 3-benzoate (E(2)) capsule was implanted subcutaneously at 24 hours before infusion of FC. The severity of brain injury and neurological deficits were measured by histological quantification and forelimb asymmetry test, respectively. The role of thioredoxin (Trx) in E(2)-mediated neuroprotective effect was examined by intrastriatal administration of a Trx reductase inhibitor, 5,5-dithiobis-(2-nitrobenzoic acid), and small interfering RNA. FC induced greater brain injury in male rats than females. E(2) treatment reduced FC-induced brain injury in both sexes. E(2) significantly increased protein level and activity of Trx in the caudate nucleus of females but not males. Administration of female rats with 5,5-dithiobis-(2-nitrobenzoic acid) or Trx small interfering RNA to ...Continue Reading

References

Nov 1, 1995·Progress in Cardiovascular Diseases·A Paganini-Hill
Oct 21, 1993·Behavioural Brain Research·R L RoofD G Stein
Jan 1, 1995·Epidemiologic Reviews·A G ThriftJ J McNeil
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Dec 1, 2001·Free Radical Biology & Medicine·J Nordberg, E S Arnér
Dec 26, 2001·The Journal of Biological Chemistry·Tsugunobu AndohChuang Chin Chiueh
Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Ya HuaGuohua Xi
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jon Nilsen, Roberta Diaz Brinton
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sang Y LeeChuang C Chiueh
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Louise D McCullough, Patricia D Hurn
Nov 15, 2003·Stroke; a Journal of Cerebral Circulation·Jimin WuGuohua Xi
Dec 20, 2005·Lancet Neurology·Guohua XiJulian T Hoff
Mar 3, 2006·Journal of Neurosurgery·Ya HuaGuohua Xi
May 13, 2006·Journal of Applied Physiology·M NickersonM Fleshner
Jun 21, 2006·Endocrine·Shotaro SuzukiPhyllis M Wise

❮ Previous
Next ❯

Citations

Apr 12, 2014·Oxidative Medicine and Cellular Longevity·Daniela Silva-AdayaJorge Guevara
Oct 9, 2014·Journal of Bioenergetics and Biomembranes·Tyler G Demarest, Margaret M McCarthy
May 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erik G HaymanJ Marc Simard
Feb 7, 2015·Stroke; a Journal of Cerebral Circulation·Sankalp GokhaleMichael L James
May 15, 2018·Translational Stroke Research·Yongqiu XieMichael L James
Aug 30, 2018·Neurotoxicity Research·Joanna A RuszkiewiczMichael Aschner
Jan 4, 2019·Journal of Molecular Neuroscience : MN·Joanna A RuszkiewiczMichael Aschner
Jul 18, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Zahra RostamiAli Ghanbari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.