Sex-specific vagal and spinal modulation of swallow and its coordination with breathing

PloS One
Alyssa HuffTeresa Pitts

Abstract

Swallow-breathing coordination is influenced by changes in lung volume, which is modulated by feedback from both vagal and spinal sensory afferents. The purpose of this study was to manipulate feedback from these afferents, with and without a simultaneous mechanical challenge (chest compression), in order to assess the influence of each sensory pathway on swallow in rats. We hypothesized that manipulation of afferent feedback would shift the occurrence of swallow toward the inspiratory phase of breathing. Afferent feedback was perturbed by lidocaine nebulization, extra-thoracic vagotomy, or lidocaine administration to the pleural space in sodium pentobarbital anesthetized rats (N = 43). These different afferent perturbations were performed both in control conditions (no chest compression), and with chest compression. Manipulating pulmonary stretch receptor-mediated volume feedback in male animals decreased swallow occurrence. Female rats appear to rely more on spinal afferent feedback, as swallow occurrence shifted to late expiration with chest compression and vagotomy or lidocaine injections. Results suggest that sex-specific mechanisms modulate swallow-breathing coordination, and that vagal feedback is inhibitory to swallow-r...Continue Reading

References

Dec 1, 1989·Journal of Applied Physiology·E van LunterenN S Cherniack
Aug 1, 1989·The Journal of Clinical Investigation·E van Lunteren, T E Dick
Jun 1, 1986·Journal of Applied Physiology·M L AitkenR B Schoene
Jan 1, 1985·Experimental Brain Research·J P Kessler, A Jean
Aug 1, 1973·Archives of Oral Biology·J A McNamara, R E Moyers
Nov 1, 1980·The Journal of Physiology·E R ArbuthnottK U Kalu
May 1, 1994·Physiology & Behavior·K UchidaT Sato
Jun 1, 1993·The Journal of Physiology·T E DickN S Cherniack
Jan 19, 2000·Experimental Brain Research·C GestreauA L Bianchi
Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Q Sang, R K Goyal
Mar 7, 2001·The Journal of Physiology·A G ZabkaG S Mitchell
Apr 19, 2002·Journal of Applied Physiology·Thom R FeroahTom Rice
Dec 31, 2002·Journal of Applied Physiology·Bonnie Martin-HarrisBobby Walters
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·François BellemareJacques Couture
Jan 1, 1961·Journal of Applied Physiology·R GILBERTJ H AUCHINCLOSS
May 1, 1962·Journal of Neurophysiology·H SHIMAZUK KUBOTA
May 6, 2006·Journal of Applied Physiology·E Fiona Bailey, Ralph F Fregosi
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Michelle A CareyDarryl C Zeldin
May 17, 2008·Dysphagia·Teresa PittsChristine Sapienza
Aug 30, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·Karen M Wheeler HeglandChristine M Sapienza
Mar 7, 2009·Journal of Applied Physiology·J M WenningerM Behan
Jun 30, 2009·Journal of Neuroscience Methods·Carlos B MantillaGary C Sieck
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huafeng LiJerry Yu
May 4, 2010·Neuroscience Research·Takeshi SuzukiKeisuke Shiba
Oct 23, 2010·Journal of Speech, Language, and Hearing Research : JSLHR·Karen Wheeler HeglandChristine M Sapienza
Feb 8, 2011·Respiratory Physiology & Neurobiology·Yacine OuahchiEric Verin
Dec 27, 2011·Experimental Physiology·Teresa PittsDonald Bolser
Jul 12, 2012·Respiratory Physiology & Neurobiology·Vincent JosephRichard Kinkead
Sep 4, 2013·Respiratory Physiology & Neurobiology·Teresa PittsDonald C Bolser
May 6, 2014·Lung·Karen Wheeler HeglandMichelle S Troche
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jorge CastroMriganka Sur
Aug 30, 2014·PloS One·Daniel G SpearmanTeresa Pitts
Oct 22, 2014·Lung·Teresa PittsDonald C Bolser

❮ Previous
Next ❯

Software Mentioned

SPSS
Swallow
Spike2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.