Sex-Specific Versus Overall Clinical Decision Limits for Cardiac Troponin I and T for the Diagnosis of Acute Myocardial Infarction: A Systematic Review

Clinical Chemistry
Dorien M KimenaiSteven J R Meex

Abstract

The overall clinical decision limits of high-sensitivity cardiac troponin I (hs-cTnI; 26 ng/L) and T (hs-cTnT; 14 ng/L) may contribute to underdiagnosis of acute myocardial infarction in women. We performed a systematic review to investigate sex-specific and overall 99th percentiles of hs-cTnI and hs-cTnT derived from healthy reference populations. We searched in PubMed and EMBASE for original studies, and by screening reference lists. Reference populations designed to establish 99th percentiles of hs-cTnI (Abbott) and/or hs-cTnT (Roche), published between January 2009 and October 2017, were included. Sex-specific and overall 99th percentile values of hs-cTnI and hs-cTnT were compared with overall clinical decision ranges (hs-cTnI, 23-30 ng/L; hs-cTnT, 13-25 ng/L). Twenty-eight studies were included in the systematic review. Of 16 hs-cTnI and 18 hs-cTnT studies, 14 (87.5%) and 11 (61.1%) studies reported lower female-specific hs-cTn cutoffs than overall clinical decision ranges, respectively. Conversely, male-specific thresholds of both hs-cTnI and hs-cTnT were in line with currently used overall thresholds, particularly hs-cTnT (90% concordance). The variation of estimated overall 99th percentiles was much higher for hs-cTnI t...Continue Reading

References

Dec 1, 1995·Hypertension·G de SimoneR A Meyer
Jun 1, 2002·Annals of Clinical Biochemistry·Paul SheehanSamuel D Vasikaran
Dec 6, 2003·Clinical Chemistry·Mauro PanteghiniUNKNOWN Committee on Standardization of Markers of Cardiac Damage of the IFCC
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Dec 5, 2009·Clinical Chemistry·Evangelos GiannitsisHugo A Katus
Mar 13, 2010·Journal of the American College of Cardiology·Maddalena PiroFilippo Crea
Aug 6, 2010·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Jan 12, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·A K SaengerA S Jaffe
Oct 4, 2011·Clinical Chemistry·Fred S AppleUNKNOWN IFCC Task Force on Clinical Applications of Cardiac Biomarkers
May 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Gus KoerbinPeter E Hickman
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Apr 11, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tar-Choon AwShiow-Pin Tan
Oct 12, 2013·Clinical Chemistry·Yader Sandoval, Fred S Apple
Nov 23, 2013·Clinical Chemistry·Allan S Jaffe, Fred S Apple
Feb 18, 2014·Journal of the American College of Cardiology·M Odette GoreJames A de Lemos
Jun 5, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Magdalena KrintusGrazyna Sypniewska
Jan 23, 2016·Heart·Dorien M KimenaiSteven J R Meex
Feb 28, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas MuellerBenjamin Dieplinger
Jun 4, 2016·Nature Reviews. Cardiology·Neha J Pagidipati, Eric D Peterson
Jun 24, 2016·Clinical Chemistry·Jacobus Petrus Johannes UngererCarel Jacobus Pretorius
Aug 25, 2016·Clinical Biochemistry·Kai M EggersBertil Lindahl
Oct 19, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Magdalena KrintusGrazyna Sypniewska
Nov 9, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dae-Hyun KoWon-Ki Min
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 7, 2017·Clinical Biochemistry·Peter E HickmanWalter P Abhayaratna
Jun 21, 2017·Clinical Chemistry·Kai M Eggers, Bertil Lindahl
Aug 2, 2017·Journal of Clinical Laboratory Analysis·Naoya AbeJunko Komatsu

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Citations

Apr 19, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Ferruccio CeriottiUNKNOWN European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group on Biological Variation
Feb 6, 2020·BioMed Research International·Xi-Ying WangJian Yang
Jul 3, 2019·European Heart Journal. Quality of Care & Clinical Outcomes·Kuan Ken Lee, Anoop S V Shah
Oct 11, 2020·Current Cardiology Reports·Lindsey TrutterMartha Gulati
Jan 19, 2021·Cardiovascular Research·Thomas E KaierMichael Marber
Apr 19, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vanda Barakett-HamadéGhassan Sleilaty
Aug 26, 2021·European Heart Journal·Ryan WereskiAndrew R Chapman

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