Sex-specific viability, sex linkage and dominance in genomic imprinting

Jeremy Van Cleve, Marcus W Feldman


Genomic imprinting is a phenomenon by which the expression of an allele at a locus depends on the parent of origin. Two different two-locus evolutionary models are presented in which a second locus modifies the imprinting status of the primary locus, which is under differential selection in males and females. In the first model, a modifier allele that imprints the primary locus invades the population when the average dominance coefficient among females and males is >12 and selection is weak. The condition for invasion is always heavily contingent upon the extent of dominance. Imprinting is more likely in the sex experiencing weaker selection only under some parameter regimes, whereas imprinting by either sex is equally likely under other regimes. The second model shows that a modifier allele that induces imprinting will increase when imprinting has a direct selective advantage. The results are not qualitatively dependent on whether the modifier locus is autosomal or X linked.


Jan 1, 1977·Annual Review of Genetics·M J Simmons, J F Crow
Jan 1, 1989·Annals of the New York Academy of Sciences·C Sapienza
Jan 1, 1987·Journal of Mathematical Biology·J F Selgrade, M Ziehe
Dec 1, 1971·Theoretical Population Biology·M W Feldman, S Karlin
May 1, 1993·Nature Genetics·N GiannoukakisC Polychronakos
Feb 1, 1997·Theoretical Population Biology·H G Spencer, M J Williams
Dec 24, 1997·Proceedings. Biological Sciences·D Haig
Jan 1, 1997·Annual Review of Genetics·M S Bartolomei, S M Tilghman
Sep 24, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R FeilP Loi
Dec 22, 1999·Development Genes and Evolution·M J O'NeillS M Tilghman
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·D J de KoningM A Groenen
Sep 22, 2000·Plant Molecular Biology·M Alleman, J Doctor
Mar 17, 2001·Nature Reviews. Genetics·W Reik, J Walter
Apr 11, 2001·Genetica·V Lloyd
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sudhir Kumar, Sankar Subramanian
Apr 27, 2002·Nature·Nicholas S Duesbery, George F Vande Woude
Jan 14, 2003·Seminars in Cell & Developmental Biology·Jörn Walter, Martina Paulsen
May 3, 2003·Nature Reviews. Genetics·Jon F Wilkins, David Haig
Jun 16, 2004·Current Opinion in Genetics & Development·Katia Delaval, Robert Feil
Sep 3, 2004·Genetics·Troy Day, Russell Bonduriansky
Apr 9, 2005·Nature Reviews. Genetics·Wolf Reik, Annabelle Lewis
Jun 1, 2005·Trends in Genetics : TIG·Jon F Wilkins
Jun 3, 2005·Genome Research·Philippe P LuediRandy L Jirtle
Jul 2, 2005·Trends in Genetics : TIG·Ian M MorisonHamish G Spencer
Sep 2, 2005·Journal of Evolutionary Biology·H G Spencer, M W Feldman
Nov 3, 2005·Evolution; International Journal of Organic Evolution·Russell Bonduriansky, Locke Rowe
Nov 24, 2006·PLoS Genetics·Andrew J Wood, Rebecca J Oakey
Dec 15, 2006·PLoS Genetics·Daniel J Gaffney, Peter D Keightley

❮ Previous
Next ❯


Aug 7, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jason B Wolf, James M Cheverud
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jason B Wolf
May 3, 2013·PLoS Genetics·Tim Connallon, Andrew G Clark
Jun 20, 2008·Genetics·Manus M Patten, David Haig
May 22, 2008·Genetics·Isabel Gordo, Paulo R A Campos
Mar 13, 2014·Heredity·J B Wolf, Y Brandvain
Jan 3, 2012·Seminars in Cell & Developmental Biology·Peter W HarrisonJudith E Mank
Apr 10, 2017·Theoretical Population Biology·S Thomas Kelly, Hamish G Spencer
Jun 15, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Alexandra R VaughnVivian Y Shi
Jul 16, 2013·Journal of Evolutionary Biology·A E Wright, J E Mank
Mar 19, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jon F WilkinsJeremy Van Cleve
Jun 22, 2013·Ecology and Evolution·Tanya M Pennell, Edward H Morrow
Jul 19, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Kim M A EndreUNKNOWN study group
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Emirjeta Bajrami, Mirko Spiroski

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.