Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A

Endocrinology
N FortunatiRoberto Frairia

Abstract

Estradiol is considered to be a critical factor in the growth induction of some breast cancer cells, like MCF-7 cell line. Among other compounds involved in the control of neoplastic mammary cell growth, cAMP has been suggested, on the other hand, to exert an antiproliferative effect. Sex steroid binding protein (SBP) sex hormone binding globulin (SHBG), the plasma carrier for both androgens and estradiol, recognizes a specific receptor located on membranes of estrogen- and androgen-sensitive tissue and cultured cells (e.g. MCF-7 cell). The interaction of estradiol with the receptor-bound SBP has been reported to induce a significant accumulation of cAMP in MCF-7 cells; in addition, a negative modulation of estradiol induced proliferation of these cells has been described after treatment with SBP. We report here a more detailed observation about the effect of SBP on MCF-7 cell estradiol-induced growth as well as the possible linkage between SBP and its membrane receptor and protein kinase A activity. MCF-7 cell growth was induced by estradiol, but the effect of estradiol was completely abolished by cell treatment with both SBP and estradiol. The inhibitory effect of SBP was highly specific. Because it was suggested that SBP mig...Continue Reading

Citations

Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Kristen L OsterlundRayna J Gonzales
Nov 13, 2008·Endocrine-related Cancer·Syed Mahfuzul AlamMing-Fong Lin
Apr 29, 1999·Journal of Endocrinological Investigation·N Fortunati
Apr 26, 2008·Breast Cancer Research and Treatment·Lucia CostantinoNicoletta Fortunati
May 11, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Emmanuel HoppéErick Legrand
Sep 23, 2009·Molecular and Cellular Endocrinology·N FortunatiR Frairia
Dec 21, 2007·Frontiers in Neuroendocrinology·C D ForadoriR J Handa
Nov 7, 2007·Frontiers in Neuroendocrinology·Guido Michels, Uta C Hoppe
Jan 20, 2006·Molecular and Cellular Endocrinology·Marilena Kampa, Elias Castanas
Jan 25, 2005·Molecular and Cellular Endocrinology·M G CatalanoN Fortunati
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Felipe Osório-CostaJosé B C Carvalheira
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Sep 28, 2002·Molecular Endocrinology·Cynthia A Heinlein, Chawnshang Chang
Mar 11, 2004·Journal of Endocrinological Investigation·N Fortunati, R Frairia
Feb 1, 1997·Breast Cancer Research and Treatment·M G CatalanoN Fortunati

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