Sex steroid receptor expression in different adipose depots is modified during midpregnancy

Molecular and Cellular Endocrinology
Sergio Rodriguez-CuencaAna Maria Proenza

Abstract

Sex hormone signalling is key in the understanding of adipose tissue metabolism during pregnancy. Sex hormones play an important role in adipose tissue metabolism by activating specific receptors that alter several steps of lipolysis and lipogenesis. We analyze steroid receptor mRNA levels in different rat adipose depots and mammary fat pad, as well as the sex hormone profile during midpregnancy, coinciding with the placentation process. Thus, progesterone and estradiol plasma levels were increased as well as testosterone levels. This hormonal profile was accompanied by low glucose to insulin ratio. PR-B, ERalpha and AR receptor densities during midpregnancy were dependent on adipose depot location. In mammary fat pad, the mRNA levels of sex hormone receptors were correlated with the growth of the depot. These results demonstrate that sex steroid hormone receptor mRNA expression during midpregnancy is tissue-specific. Our results agree with the idea that the increased estrogenic and androgenic signalling could be addressed to reducing the lipogenic state in early pregnancy exerted mainly by progesterone and to prepare adipose tissue for the beginning of the catabolic phase in late pregnancy in a depot-specific manner.

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Citations

Jan 6, 2010·Environmental Health Perspectives·Matthew P Longnecker
May 29, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Ewa StelmanskaJulian Swierczynski
Jan 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Therese M RothKate F Barald
May 16, 2008·American Journal of Medical Genetics. Part a·Therese M RothKate F Barald
May 27, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Ana AlonsoCelestino González
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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