Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs

Tissue & Cell
Luiz Gustavo de Almeida ChuffaAlfredo Feio da Maia Lima

Abstract

In Polycystic Ovaries (PCOs), the dynamics of sex hormone receptors and follicle-related apoptotic signaling remain unknown. In this study, we investigated the expression of androgen receptors (AR), estrogen receptors (ERα and ERβ), and apoptosis-related molecules (BAX, active caspase-3, Bcl-2 and Survivin) on different follicular stages of PCOs in adult dogs. Clinical evidences of high estradiol and testosterone levels, persistent estrus and vaginal discharge were observed. Inhibin B immunolabeling was increased in primary and 2 to 5-mm follicles, and a marked epithelial hyperplasia was common in the ovarian surface. Ovarian epithelia and primary follicles showed low expression of AR, ERα, and ERβ, whereas a moderate immunoexpression of AR was found in theca cells of secondary follicles and cysts. In PCOs, growing follicles displayed ERα expression, and secondary follicles exhibited higher ERβ expression. In addition, while few ERα-positive cells were found in the cysts, ERβ was moderately expressed in growing follicles and cysts. BAX was upregulated in the ovarian epithelium, primary follicles, and in the wall of follicular cysts. Active caspase-3 was significantly downregulated in the epithelium, primary follicles, and folli...Continue Reading

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Citations

Nov 30, 2016·Journal of Bioenergetics and Biomembranes·Guo-Min ZhangZhi-Hai Lei
May 12, 2018·Journal of Cellular Biochemistry·Saeid NekoonamFardin Amidi
Oct 12, 2018·Journal of Veterinary Science·Yvonne KnaufAxel Wehrend
Jan 13, 2021·Topics in Companion Animal Medicine·Jisna K SasidharanNarayanan Krishnaswamy
Jul 25, 2020·Veterinary and Comparative Oncology·Tao ZhangChangwei Qiu

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