Sex steroid regulation of leukocyte traffic in human decidua

Human Reproduction
H O CritchleyD T Baird

Abstract

Endometrial leukocyte subpopulations vary over the reproductive cycle, but no data exist on the mechanism regulating their recruitment into uterine tissue. This study has evaluated the role of progesterone in the recruitment of selected leukocyte populations in early pregnancy decidua. Decidua was collected from women in early pregnancy at the time of vacuum aspiration of the uterus 6, 12, 24 and 36 h after taking 200 mg mifepristone (RU486). Standard immunohistochemical techniques were employed to demonstrate the selected leukocyte populations in decidual tissue and these were analysed using imaged analysis. Fresh decidua was incubated in medium for 24 h and supernatants assayed for interleukin (IL-8) (neutrophil chemotactic factor) and MCP-1 (monocyte chemoattractant protein-1) content. Analysis of variance demonstrated a significant increase in tissue monocyte number in decidua 12-36 h after mifepristone administration. No significant changes in other leukocyte subpopulations were observed. Decidua IL-8 concentrations were significantly increased (P = 0.019) 6 h after mifepristone and decidual MCP-1 concentration rose (non-significant) and fell significantly (P = 0.029) between 6 and 12 h after mifepristone. Progesterone wit...Continue Reading

Citations

Dec 12, 2003·Steroids·Hilary O D CritchleyDavid T Baird
Jun 9, 1999·Fertility and Sterility·J A García-Velasco, A Arici
Sep 8, 1998·Journal of Reproductive Immunology·C SimónA Pellicer
May 15, 2007·Current Opinion in Obstetrics & Gynecology·Natalie J Hannan, Lois A Salamonsen
Dec 3, 2003·Reproductive Biology and Endocrinology : RB&E·Anne E KingRodney W Kelly
Jan 23, 2003·Reproductive Biomedicine Online·A PellicerC Simón
Oct 12, 2010·Placenta·I Tirado-GonzálezE G Olivares
May 2, 2009·Journal of Reproductive Immunology·N Gomez-LopezF Vadillo-Ortega
Jul 10, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Vasso Terzidou
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-KimAlice Gilman-Sachs
Jun 4, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·David T Baird
Jun 12, 2013·Vascular Pharmacology·Lauren M GoddardM Luisa Iruela-Arispe
Jan 5, 2011·Journal of Minimally Invasive Gynecology·George A VilosAngelos G Vilos
Jul 13, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M Sean EsplinEli Y Adashi
Feb 18, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Magali AncelinMartine Perrot-Applanat
Oct 18, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M S EsplinE Y Adashi
Jan 18, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·T ChaiworapongsaS Edwin
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Carolyn L DunnRodney W Kelly
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley
Jun 4, 2010·Journal of Leukocyte Biology·Nardhy Gomez-LopezDavid M Olson
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Umit A KayisliAydin Arici
Oct 12, 2001·Annals of the New York Academy of Sciences·C SimónA Pellicer
Oct 22, 2003·Reproductive Biomedicine Online·Carolyn L DunnHilary O D Critchley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.