PMID: 7542859Jun 12, 1995Paper

Sex steroids and epidermal growth factor in benign prostatic hyperplasia (BPH)

Annals of the New York Academy of Sciences
F Sciarra

Abstract

Androgens provide the primary signal for the onset of DNA synthesis and cell division in normal prostate and benign prostatic hyperplasia (BPH). It is possible, however, that androgen mitogenic activity is in part indirect and mediated by peptide growth factors. In LNCaP cell lines, R1881 added to DCC-FCS medium increases DNA, epidermal growth factor (EGF) and EGF receptor (EGFR) levels: the antiandrogen hydroxy-flutamide prevents the increase of the growth factor and increases its receptor. In BPH tissue removed by transvesical prostatectomy, DHT, testosterone, 3 alpha-androstanediol and nuclear androgen receptors (AR) show a positive linear correlation with EGF: treatment with flutamide decreases significantly the EGF production. Androgens, therefore, represent important modulatory factors of prostatic EGF release. Moreover, androgens and EGF downregulate EGFR, which is probably internalized into the cell and degraded by lisosomes: in fact, a negative linear correlation between EGF, nuclear AR and the high- and low-affinity binding of EGFR is observed. These findings support the hypothesis that the growth-promoting effects of androgens in the prostate are in part mediated by peptide growth factors. The inhibitory effect of an...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J GellerG Niwayama
Jan 1, 1975·Vitamins and Hormones·N BruchovskyS Craven
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C LubranoF Di Silverio
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Jan 1, 1973·Advances in Experimental Medicine and Biology·D Rodbard
Jan 1, 1984·The Prostate·J T Isaacs
Oct 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C LubranoF Sciarra

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Citations

Jun 23, 2000·Archives of Andrology·F Sciarra, V Toscano
Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·T KealeyR Guy

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