PMID: 19912775Dec 1, 1990Paper

Sex steroids and fos expression in the CNS of prepubertal and newborn rats

Molecular and Cellular Neurosciences
R B GibbsD W Pfaff

Abstract

Fos-like immunoreactivity (IR) within estrogen-concentrating regions of the hypothalamus and within sexually dimorphic regions of the hypothalamus and spinal cord was studied both as a function of estrogen treatment and during specific stages of postnatal development. Two sets of experiments were performed. First, Fos expression in the arcuate (Arc) and ventromedial (VMN) nuclei of the hypothalamus of 25-day-old female rats was examined 1, 3, and 6 h after estrogen treatment. Since (1) estrogen has been shown to stimulate synapse formation in the Arc of 25-day-old female rats, and (2) the Arc and VMN express among the highest levels of estrogen receptor in brain, we hypothesized that estrogen treatment might lead to a rapid induction of Fos-like IR in these areas. Second, Fos expression in the brain and spinal cord of newborn and 10-day-old male and female rats was examined and compared. Particular attention was given to specific sexually dimorphic nuclei of the hypothalamus and spinal cord and to regions of the mediobasal hypothalamus known to contain high levels of gonadal steroid receptors. Since many studies have shown that neuronal development within sexually dimorphic areas of the hypothalamus and spinal cord is influence...Continue Reading

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Citations

Jan 14, 1994·Brain Research. Developmental Brain Research·F MunellR M Gubits
May 31, 1996·Brain Research. Developmental Brain Research·G M KasofJ I Morgan
Nov 1, 1992·Brain Research. Molecular Brain Research·R J SmeyneJ I Morgan
Mar 1, 1993·Brain Research. Molecular Brain Research·F E JensenG D Mower
Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W E KaufmannP F Worley
Oct 2, 2003·Brain Research. Developmental Brain Research·Sylvia E PérezElliott J Mufson
Nov 13, 2001·Behavioural Brain Research·C P Wiedenmayer, G A Barr
Apr 22, 2005·Journal of Neuroendocrinology·K M Olesen, A P Auger
Mar 16, 2021·Frontiers in Behavioral Neuroscience·Sydney A Rowson, Kristen E Pleil

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