PMID: 7370784May 12, 1980Paper

Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. II. Morphological correlates and hormonal specificity

Brain Research
C D Toran-Allerand

Abstract

In studies designed to elucidate morphogenetic mechanisms involved in the neurogenesis of sexual differentiation of the brain, estradiol or testosterone was added to organotypic cultures of the newborn mouse hypothalamus and preoptic area. Both gonadal hormones selectively accelerated and enhanced neuritic proliferation in specific regions of the preoptic area and infundibular/premamillary levels. This regional localization suggests specific induction of neuritic branching perhaps only in those neurons shown by autoradiography to contain the steroid receptor. The significance of estradiol per se is emphasized by the reduction and retardation of neuritic outgrowth in those same regions following exposure to steroid-deficient medium or blockade of the nuclear receptor (CI-628) and by the failure of testosterone alone to induce a significant response. The importance of aromatization of androgen to estradiol is supported by the failure of non-aromatizable 5 alpha-dihydrotestosterone to elicit an effect even in the presence of estradiol. This apparent hormonal specificity suggests that the neuritic response may be a component of sexual differentitation and that the trophic effects of estradiol may influence significantly the ontogen...Continue Reading

References

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Citations

Sep 16, 1996·The Journal of Comparative Neurology·J G Whitesides, A S LaMantia
Dec 18, 2001·Journal of Neuroscience Research·M J Cambiasso, H F Carrer
Aug 1, 1994·Journal of Neurobiology·F SohrabjiC D Toran-Allerand
Jul 8, 1982·Brain Research·T A Milner, R Loy
Apr 1, 1985·Brain Research·D Keefer, C Holderegger
Jun 1, 1981·Molecular and Cellular Endocrinology·M VértesS Kovács
Apr 1, 1988·Neuroscience·G F JirikowskiW E Stumpf
Jan 1, 1983·Psychoneuroendocrinology·A Jost
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R P Hammer, C D Jacobson
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Uchibori, S Kawashima
Jan 1, 1987·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I ReisertJ Lauder
Feb 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Takagi, S Kawashima
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·C D Toran-Allerand
Aug 17, 2001·Brain Research. Developmental Brain Research·M L DugardJ Caston

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