Sex steroids in androgen-secreting adrenocortical tumors: clinical and hormonal features in comparison with non-tumoral causes of androgen excess

European Journal of Endocrinology
Catarina B d'AlvaJerôme Bertherat

Abstract

Adrenocortical tumors (ACT) account for no more than 0.2% of the causes of androgen excess (AE). Conversely, these rare tumors have a very poor prognosis. It is difficult and important to exclude this diagnosis whenever there is AE. Retrospective investigation of androgen profiles in a large consecutive series of androgen-secreting (AS) ACT to assess their relative diagnostic value. A total of 44 consecutive female patients with ACT-AS and a comparison group of 102 women with non-tumor causes of AE (NTAE). Patients with ACT-AS were older than the ones with NTAE (37.7 vs 24.8 years; P<0.001) and the prevalence of hirsutism, acne, and oligo/amenorrhea were not different. Free testosterone was the most commonly elevated androgen in ACT-AS (94%), followed by androstenedione (90%), DHEAS (82%), and total testosterone (76%), and all three androgens were simultaneously elevated in 56% of the cases. Androgen serum levels became subnormal in all ACT-AS patients after complete tumor removal. In NTAE, the most commonly elevated androgen was androstenedione (93%), while all three androgens were elevated in only 22% of the cases. Free testosterone values above 6.85 pg/ml (23.6 pmol/l) had the best diagnostic value for ACT-AS (sensitivity 82...Continue Reading

Citations

Apr 19, 2011·Journal of Feline Medicine and Surgery·Erika N MelerJames F Naughton
May 3, 2011·American Journal of Veterinary Research·Kellie A FecteauJack W Oliver
Sep 8, 2011·European Journal of Endocrinology·Julie SarfatiUNKNOWN Study Group Hyperandrogenism in Postmenopausal Women
Jan 26, 2010·Annales d'endocrinologie·M PugeatUNKNOWN French Endocrine Society
Dec 21, 2010·Seminars in Oncology·Dominic CavlanAshley Grossman
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Lionel GroussinFlorence Tenenbaum
Dec 17, 2020·Journal of the Endocrine Society·Eng-Loon Tng, Jeanne May May Tan
Mar 5, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eng-Loon Tng, Jeanne May-May Tan
Nov 26, 2009·The Medical Clinics of North America·Margarita S LolisAlan R Shalita

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