Sex steroids increase cholesterol 7alpha-hydroxylase mRNA in nonhuman primates

Metabolism: Clinical and Experimental
P L ColvinM G Sorci-Thomas

Abstract

One mechanism that may account for our prior observation that oral contraceptives decrease the hepatic cholesterol concentration independently of the low-density lipoprotein (LDL) receptor in sexually intact nonhuman primates is that sex hormones increase biliary cholesterol secretion by increasing hepatic mRNA abundance for cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in the conversion of cholesterol into bile acids. To examine the independent effect of estrogen, progestin, and combined estrogen and progestin on the hepatic cholesterol concentration and cholesterol 7alpha-hydroxylase mRNA abundance, 34 ovariectomized adult female cynomolgus monkeys were fed a moderately atherogenic diet for 12 weeks with either oral conjugated equine estrogen ([CEE] n = 8), medroxyprogesterone acetate ([MPA] n = 9), or combined CEE + MPA (n = 9) and compared with a control group (n = 8) that did not receive exogenous sex hormones. After 12 weeks, hepatic cholesterol was significantly lower in CEE-treated (6.2 +/- 1.2 mg/g liver) and CEE + MPA-treated (6.4 +/- 0.9 mg/g liver) animals compared with the control (12.6 +/- 1.9 mg/g liver) and MPA-treated (14.6 +/- 1.6 mg/g liver) groups. Hepatic cholesterol 7alpha-hydroxylase mRNA abund...Continue Reading

References

Nov 23, 1978·The New England Journal of Medicine·L J Bennion, S M Grundy
Nov 30, 1978·The New England Journal of Medicine·L J Bennion, S M Grundy
Jan 22, 1976·The New England Journal of Medicine·L J BennionP H Bennett
Nov 1, 1992·Gastroenterology·B AngelinK Einarsson
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J S ParksL L Rudel
Jun 1, 1990·The Journal of Clinical Endocrinology and Metabolism·P L ColvinD Applebaum-Bowden
Mar 1, 1989·American Journal of Obstetrics and Gynecology·G D'AmatoG Misciagna
Feb 1, 1987·Seminars in Liver Disease·M J Kreek
Sep 1, 1983·American Journal of Obstetrics and Gynecology·A BasdevantB Guy-Grand
Jan 1, 1980·Metabolism: Clinical and Experimental·L J BennionB V Howard
Nov 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P L ColvinM G Sorci-Thomas
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J D WagnerM R Adams

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Citations

Jul 6, 2000·The Journal of Nutritional Biochemistry·E A LucasB H Arjmandi
Nov 13, 2004·The Journal of Nutritional Biochemistry·E SohnB H Arjmandi
Sep 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kylie KavanaghJanice D Wagner
Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Xiong LiuKiyoshi Ebihara
Oct 7, 2011·Cardiovascular Therapeutics·Tim R SullivanMarkus Herrmann
Nov 25, 2005·American Journal of Reproductive Immunology : AJRI·Gireesh RajashekaraGary Splitter
Jan 5, 2000·Physiological Reviews·G J Schroepfer

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