Sex steroids possess distinct stimulus properties in female and male mice

Brain Research Bulletin
B W PeetersC L Broekkamp

Abstract

Very few studies have investigated the aversive properties of sex steroids in animals. We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste aversion in both female and male mice; however, testosterone-propionate and progesterone had an effect only in females. These results show that sex steroids have intrinsic aversive properties. The different effects of the steroids in males and females cannot simply be explained by nausea induction or novelty.

References

Dec 1, 1978·Journal of Comparative and Physiological Psychology·C B SengstakeJ H Thrower
May 1, 1976·Animal Learning & Behavior·K C Chambers, C B Sengstake
Sep 1, 1976·Journal of Comparative and Physiological Psychology·K C Chambers
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·T Hunt, Z Amit
Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·R P HeinsbroekN E van de Poll
Dec 23, 1967·Nature·J StewartE Kaczender

Citations

Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·B W Peeters, C L Broekkamp
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Jovita F Randall-Thompson, A L Riley
Jan 12, 2005·Physiology & Behavior·Houri HintiryanK C Chambers
Jul 12, 2005·Pharmacology, Biochemistry, and Behavior·Gregory D BusseA L Riley

Related Concepts

Metazoa
Conditioning (Psychology)
Dose-Response Relationship, Drug
Aerodiol
Mouse, Inbred ICRC
Progesterone, (17 alpha)-Isomer
Taste Perception
Testolin
Mouse, Swiss

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