Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens

Pharmacology, Biochemistry, and Behavior
Y C LiuJ D Salamone

Abstract

Considerable neurochemical evidence links dopamine (DA) in nucleus accumbens (NAcc) to male sexual behavior. The present experiments were conducted to extend this information to the male's sexual response to remote stimuli from estrous female (noncontact erection; NCE). Male rats were tested for copulation and NCE after either 6-hydroxydopamine (6-OHDA) or radiofrequency (RF) lesions in NAcc). Males with an average 78% depletion of DA in NAcc had a lower incidence of NCE, longer latency to display NCE, and fewer erections. DA-depleted males also had less locomotor activity after injections of d-amphetamine, and reductions in apomorphine-induced yawning, but a normal incidence of penile erection. Males with RF lesions of the NAcc had longer NCE latencies. All males copulated to ejaculation after either 6-OHDA or RF lesions with little or no deficit, although the 6-OHDA-treated males had longer intromission latencies. The NCE deficit supports the hypothesized role of NAcc DA in arousal processes in responding to remote cues from estrous females. The minimal effect of lesions on copulation suggests that the presence of additional proximal stimulation during copulation may overcome the deficits induced by DA depletions or lesions i...Continue Reading

References

Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·E Mogilnicka, V Klimek
Oct 22, 1990·Brain Research·J G PfausH C Fibiger
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·T W RobbinsB J Everitt
Jan 21, 1986·European Journal of Pharmacology·G SerraG L Gessa
Aug 3, 1984·European Journal of Pharmacology·A J GowerC L Broekkamp
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·B D Sachs
Jun 1, 1994·Physiology & Behavior·B D SachsJ H Natoli
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson

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Citations

Jun 22, 1999·Hormones and Behavior·J ManzoB D Sachs
Nov 26, 2003·Physiology & Behavior·Monica L AndersenSergio Tufik
Jul 6, 2000·Neuroscience and Biobehavioral Reviews·F Giuliano, O Rampin
Feb 11, 2000·Current Opinion in Urology·C G McMahon, R Samali
Nov 23, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helen E FisherLucy L Brown
Feb 2, 2013·Endocrinology·Margaret R Bell, Cheryl L Sisk
Feb 16, 2015·Journal of the Neurological Sciences·Jong-Ho ParkWuwei Feng
May 21, 2009·The Journal of Sexual Medicine·James G Pfaus
May 25, 2012·The Journal of Sexual Medicine·Carolyn M Dundon, Alessandra H Rellini
Oct 30, 2010·The Journal of Sexual Medicine·Arthur L BurnettZhong C Xin
Aug 30, 2008·Physiology & Behavior·Miguel Angel GuevaraMarisela Hernández-González
Sep 11, 2007·European Journal of Pharmacology·Jocelien D A OlivierJan G Veening
Nov 17, 2005·BJU International·Ion G Motofei, David L Rowland
Apr 3, 2003·The European Journal of Neuroscience·Maria Rosaria MelisAntonio Argiolas
Sep 15, 2009·Behavioural Brain Research·Michal BialyEvgeni Nikolaev
Feb 7, 2002·Expert Opinion on Investigational Drugs·John P Mulhall
Oct 20, 2010·Neuroscience and Biobehavioral Reviews·Danielle S Stolzenberg, Michael Numan
Jan 30, 2013·Pharmacology, Biochemistry, and Behavior·Owen R Floody, Laina G Lusk
May 14, 2016·Physiology & Behavior·Enrique Hernández-ArteagaHerlinda Bonilla Jaime
Dec 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaret E BalfourLique M Coolen
Mar 17, 2007·The International Journal of Neuroscience·Marcello Spinella
Mar 30, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bérangère DetrauxAlban de Kerchove d'Exaerde

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