Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance

BMC Biology
Arunas L RadzvilaviciusA Pomiankowski

Abstract

Mitochondria are predominantly inherited from the maternal gamete, even in unicellular organisms. Yet an extraordinary array of mechanisms enforce uniparental inheritance, which implies shifting selection pressures and multiple origins. We consider how this high turnover in mechanisms controlling uniparental inheritance arises using a novel evolutionary model in which control of mitochondrial transmission occurs either during spermatogenesis (by paternal nuclear genes) or at/after fertilization (by maternal nuclear genes). The model treats paternal leakage as an evolvable trait. Our evolutionary analysis shows that maternal control consistently favours strict uniparental inheritance with complete exclusion of sperm mitochondria, whereas some degree of paternal leakage of mitochondria is an expected outcome under paternal control. This difference arises because mito-nuclear linkage builds up with maternal control, allowing the greater variance created by asymmetric inheritance to boost the efficiency of purifying selection and bring benefits in the long term. In contrast, under paternal control, mito-nuclear linkage tends to be much weaker, giving greater advantage to the mixing of cytotypes, which improves mean fitness in the s...Continue Reading

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Citations

May 29, 2018·Journal of Evolutionary Biology·Anaïs TilquinHanna Kokko
Mar 28, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·R C Vaught, D K Dowling
Aug 2, 2019·The Plant Journal : for Cell and Molecular Biology·Thamali KariyawasamJae-Hyeok Lee
Feb 15, 2020·Scientific Reports·Eirini-Slavka PolovinaEmmanuel D Ladoukakis
Jun 4, 2020·International Journal of Molecular Sciences·Hector MendozaJan Schirawski
Mar 18, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Arunas Radzvilavicius
Mar 2, 2021·Journal of Evolutionary Biology·Arunas RadzvilaviciusIain G Johnston
Jul 3, 2021·Life·Maria-Eleni Parakatselaki, Emmanuel D Ladoukakis

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