PMID: 3757970Oct 1, 1986Paper

Sexual differences in the distribution and retention of organic and inorganic mercury in methyl mercury-treated rats

Environmental Research
D J ThomasL L Hall

Abstract

At 56 days of age, male and female Long-Evans rats received 1 mumole of 203Hg-labeled methyl mercuric chloride per kilogram sc and total, organic, and inorganic mercury contents and concentrations in tissues were determined for up to 98 days postdosing. Whole body clearance of mercury was faster in females than in males, and females attained higher peak percentages of the methyl mercury dose in kidney and brain than did males. Females had significantly higher mean percentages of the mercury dose present in the kidney and brain as organic or total mercury and in brain as inorganic mercury than did males. Males had significantly higher mean percentages of the dose present as organic or total mercury in pelt and whole body than did females. When expressed on a concentration basis, the only significant sexual difference was in the higher average concentration of organic mercury in the kidneys of females. When expressed on a tissue content basis, significant male-female differences in the kinetics (sex X time interactions) of organic mercury retention were found in kidney, brain, skeletal muscle, pelt, and whole body. Significant sex X time interactions in the concentrations of organic mercury were found in kidney, skeletal muscle, ...Continue Reading

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Citations

Jul 1, 1987·Archives of Environmental Contamination and Toxicology·C D WrenP M Stokes
Jan 1, 1993·Life Sciences·F F Farris, R L Dedrick
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Jul 27, 2021·Environmental Research·Peggy Hiu Ying ChanHugh Simon Lam

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