Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats

Annals of the New York Academy of Sciences
H TsukamuraKei-Ichiro Maeda

Abstract

The brain mechanism regulating GnRH/luteinizing hormone (LH) release is sexually differentiated in rodents. Estrogen induces a GnRH/LH surge in females but not in males. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) have been reported to be sexually dimorphic and suggested to be involved in the GnRH/LH surge generation. Neonatal testicular androgen may cause the reduction of AVPV kisspeptin expression and a lack of LH surge in male rats. Thus, it is plausible that perinatal testicular androgen causes defeminization of the AVPV kisspeptin system, resulting in the loss of the surge system in male rats.

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Citations

Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margarita C Currás-Collazo
Sep 20, 2012·Endocrinology·Robert L Goodman, Michael N Lehman
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiroaki OkamuraYoshihiro Wakabayashi
Jun 26, 2012·Frontiers in Neuroendocrinology·Matthew C Poling, Alexander S Kauffman
Jun 8, 2014·Frontiers in Neuroendocrinology·Richard PietAllan E Herbison
May 21, 2016·Nature Reviews. Endocrinology·Allan E Herbison
Jul 2, 2016·Molecular and Cellular Endocrinology·Matthew BeymerValérie Simonneaux
Jan 22, 2019·The Journal of Reproduction and Development·Chikaya DeuraHiroko Tsukamura
Aug 28, 2020·Frontiers in Neuroscience·Shinji Tsukahara, Masahiro Morishita
Jun 6, 2019·Frontiers in Endocrinology·Yoshihisa UenoyamaHiroko Tsukamura
Jan 21, 2020·The Journal of Reproduction and Development·Kei HorihataHiroko Tsukamura
Jan 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mayuko NagaeHiroko Tsukamura
Mar 13, 2021·General and Comparative Endocrinology·Hiroko Tsukamura

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