Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Laura C D PomattoKelvin J A Davies

Abstract

External and internal stimuli cause modifications to gene and biochemical pathways. In turn, demonstrating that biological systems continuously make short-term adaptations both to set-points, and to the range of "normal" capacity, due to mild conditional changes, or to subtoxic, nondamaging levels of chemical agents. This is termed as "Adaptive Homeostasis," defined with the following: "The transient expansion or contraction of the homeostatic range in response to exposure to sub-toxic, nondamaging, signaling molecules or events, or the removal or cessation of such molecules or events." Research from several laboratories, including our own, found that adaptive homeostasis declines with age in organisms as diverse as worms, flies, and mammals, and decreases with senescence in mammalian cell cultures. We suggest that diminishing adaptive homeostasis may play a causal role as a factor responsible for the aging phenotype. Furthermore, although studies of humans, animals, and model organisms are often limited to a single sex, and cell culture studies may even be conducted with lines whose donor's sex was unknown, studies reveal distinct sexual dimorphism in adaptive homeostasis. Interestingly, although young males and females may ex...Continue Reading

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Citations

Mar 6, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jie ShenQing Xiao
Mar 16, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonas Mengel-FromLene Christiansen
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Dec 18, 2019·Sexual Abuse : a Journal of Research and Treatment·Pascalle SpaanBouke Wartna
Jul 30, 2019·Aging·Cory W BaumannLaDora V Thompson
Dec 23, 2017·GeroScience·Joanna M S DaviesKelvin J A Davies
Dec 7, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James W Curtsinger
May 17, 2018·Frontiers in Physiology·Kelvin J A Davies
May 11, 2018·Free Radical Research·Alessandra das Graças FedoceKelvin J A Davies
Nov 10, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jie LiuCurtis D Klaassen
Sep 1, 2020·Free Radical Biology & Medicine·Ethan L Ostrom, Tinna Traustadóttir
Mar 24, 2020·Redox Biology·John TowerKelvin J A Davies
May 14, 2021·ELife·Sara Hägg, Juulia Jylhävä
Oct 14, 2017·The Journal of Physiology·Laura C D Pomatto, Kelvin J A Davies
Sep 9, 2021·The Journal of Experimental Biology·Jocelyn P ColellaMatthew D MacManes

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