Sexual dimorphism in copackaging of luteinizing hormone-releasing hormone and galanin into neurosecretory vesicles of hypophysiotrophic neurons: estrogen dependency

Endocrinology
Z LipositsI Merchenthaler

Abstract

Hypophysiotrophic neurons projecting to hypophyseal portal vessels in the median eminence of the hypothalamus maintain the operation of the master gland, the pituitary, by secreting releasing and release-inhibiting hormones into the bloodstream. LHRH, synthesized in neurons of the rat prosencephalon, is one of the key substances that governs the anterior pituitary-gonadal axis. Recently, it has been shown that the peptide galanin (GAL) is coproduced in a subpopulation of LHRH neurons and is a potent modulator of central processes regulating reproduction. A better understanding of the secretory mechanisms involved in pulsatile hormone release from LHRH axons of the median eminence requires exploration of the organelle domain that displays the cosynthesized peptides in terminal boutons. This study shows that LHRH- and GAL-immunoreactive axons overlap heavily in the lateral part of the median eminence. Double fluorescent labeling revealed colocalization of the peptides at the level of single axon terminals. By means of dual colloidal gold immunolabeling, LHRH and GAL were detected in the same secretory vesicles at the ultrastructural level. The incidence of colocalizing vesicles was high in the female (45%) and low in the male (3%...Continue Reading

Citations

Jul 19, 2006·Cell and Tissue Research·Chiara SalioAdalberto Merighi
Jan 21, 2003·Biology of Reproduction·Joseph R ScheffenAngela C Bauer-Dantoin
Apr 11, 2009·Journal de la Société de biologie·Yves TilletIsabelle Franceschini
Sep 17, 2009·The Journal of Comparative Neurology·Weiling YinAndrea C Gore
Aug 3, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A MilewiczU Tworowska

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