Apr 27, 2020

Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo

bioRxiv
Fabien DelahayeFrancine H Einstein

Abstract

SARS-CoV-2 emerged in China at the end of 2019 and has rapidly become a pandemic with roughly 2.7 million recorded COVID-19 cases and greater than 189,000 recorded deaths by April 23rd, 2020 (www.WHO.org). There are no FDA approved antivirals or vaccines for any coronavirus, including SARS-CoV-2. Current treatments for COVID-19 are limited to supportive therapies and off-label use of FDA approved drugs. Rapid development and human testing of potential antivirals is greatly needed. A quick way to test compounds with potential antiviral activity is through drug repurposing. Numerous drugs are already approved for human use and subsequently there is a good understanding of their safety profiles and potential side effects, making them easier to fast-track to clinical studies in COVID-19 patients. Here, we present data on the antiviral activity of 20 FDA approved drugs against SARS-CoV-2 that also inhibit SARS-CoV and MERS-CoV. We found that 17 of these also inhibit SARS-CoV-2 at a range of IC50 values at non-cytotoxic concentrations. We directly follow up with 7 of these to demonstrate all are capable of inhibiting infectious SARS-CoV-2 production. Moreover, we have evaluated two of these, chloroquine and chlorpromazine in vivo usi...Continue Reading

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Mentioned in this Paper

Biological Markers
Metabolic Process, Cellular
Adult Disease
Cell Aging
Small for Gestational Age
Entire Fetal Lower Extremities
CD34
Genes
Glucose Homeostasis
Chronic Disease

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