Sexual dimorphism in rabbit aortic endothelial function under acute hyperglycemic conditions and gender-specific responses to acute 17beta-estradiol

American Journal of Physiology. Heart and Circulatory Physiology
Aditya GoelRoshanak Rahimian

Abstract

Epidemiological data suggest that hyperglycemia abrogates the gender-based cardiovascular protection possibly associated with estrogens. This study was designed to investigate 1) whether rabbit aortic rings show gender differences in the development of abnormal endothelium-dependent vasodilation (EDV) under acute hyperglycemic conditions, 2) the potential role of PKC isoforms and superoxide (O2-) in acute hyperglycemia-induced vascular dysfunction, and 3) the effect of acute estrogen administration on hyperglycemia-induced endothelial dysfunction in male and female rabbits. EDV to ACh was determined before and after 3 h of treatment with high glucose (HG) in phenylephrine-precontracted aortic rings from male and female New Zealand White rabbits. Similar experiments were conducted in the presence of inhibitors of PKC-alpha, PKC-beta, and PKC-delta or an O2- scavenger. The effect of acute estrogen administration was evaluated in the presence and absence of HG. Finally, mRNA expression of PKC isoforms was measured by real-time PCR. We found that 1) 3 h of incubation with HG impairs EDV to a greater extent in female than male aorta, 2) inhibition of PKC-beta or O2- prevents HG-induced impairment of EDV in female aorta, 3) acute 17b...Continue Reading

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Citations

Feb 5, 2016·Canadian Journal of Physiology and Pharmacology·Xiaoyuan HanRoshanak Rahimian
Jul 15, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hee Kyoung JooByeong Hwa Jeon
Sep 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rui ZhangRoshanak Rahimian
Dec 14, 2011·Experimental Neurology·Elizabeth K Joseph, Jon D Levine
Jun 15, 2021·Frontiers in Physiology·Natacha FournyLuc Bertrand

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