Sexual dimorphism in rodent models of hypertension and atherosclerosis.

British Journal of Pharmacology
Kristen J BubbAmrita Ahluwalia

Abstract

Approximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect, investigation of the mechanisms underlying the protection that premenopausal females enjoy from cardiovascular-related disease and mortality is of interest. In this review, we discuss the essential role that rodent animal models play in enabling this field of research. In particular, we focus our discussion on models of hypertension and atherosclerosis.

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Citations

Jul 3, 2013·Physiology·Margaret A Zimmerman, Jennifer C Sullivan
Dec 4, 2014·International Journal of Cardiology·Flavia FranconiIlaria Campesi
Jun 15, 2013·British Journal of Pharmacology·Loubina FazalJane-Lise Samuel
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Oct 16, 2020·Nephrology·Ixchel Lima-Posada, Norma A Bobadilla
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Feb 16, 2021·American Journal of Physiology. Renal Physiology·Catalina Sierra-RamosDiego Alvarez de la Rosa
Mar 2, 2021·Endocrinology·Tharini SivasubramaniyamMinna Woo

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