Sexual dimorphism in stress-induced changes in adrenergic and muscarinic receptor densities in the lung of wild type and corticotropin-releasing hormone-knockout mice

Stress : the International Journal on the Biology of Stress
Martina NovakovaJaromir Myslivecek

Abstract

We tested the hypothesis that single and repeated immobilization stress affect densities of alpha(1)-adrenoceptor (alpha(1)-AR) and beta-AR subtypes, muscarinic receptors (MR), adenylyl cyclase activity (AC) and phospholipase C activity (PLC) in lungs of male and female wild type (WT) and corticotropin-releasing hormone gene (CRH-knockout (KO)) disrupted mice. We found sex differences in the basal levels of alpha(1)-AR subtypes (females had 2-3 times higher density of receptors than males) and MR (males had twice the density found in females). In marked contrast, beta-AR subtype densities did not differ between sexes. CRH gene disruption decreased all three studied receptors in intact mice (to 20-50% of WT) in both sexes (except beta(1)-AR in females). Stress induced sexually dimorphic responses, while all alpha(1)-AR subtypes decreased in females (to 30% of control approximately), only alpha(1A)-AR level diminished (about 50%) in males. beta(1)-AR decreased in males (to about 40%) but remained stable in females. beta(2)-AR diminished in females (to about 20-60%) and also in males (to about 30-60%). MR decreased in both sexes (approximately to 50%). AC activity diminished in males (to < 50%) while PLC activity was not changed. ...Continue Reading

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Citations

Feb 12, 2013·Brain Research Bulletin·Jan BenesJaromir Myslivecek
Jun 9, 2012·Journal of Applied Physiology·Hélène HaddenDonald Massaro
Jan 15, 2015·Stress : the International Journal on the Biology of Stress·Hana TomankovaJaromir Myslivecek
Nov 23, 2016·Stress : the International Journal on the Biology of Stress·Paulina ValuskovaJaromir Myslivecek
Feb 12, 2019·Scientific Reports·Eva VarejkovaJaromir Myslivecek
Aug 9, 2017·Cellular and Molecular Neurobiology·Eva VarejkovaJaromir Myslivecek

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