Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats

Steroids
Aliesha González-ArenasI Camacho-Arroyo

Abstract

Progesterone and estradiol play an important role in the regulation of lung functions such as ventilation and vasoconstriction. The genomic actions of progesterone and estradiol are mediated by their nuclear receptors: progesterone receptors (PR) and estrogen receptors (ER). These actions are linked to interactions between steroid receptors and some cofactors that function as coactivators or corepressors. In this work we determined the content of PR isoforms, ER-beta, one coactivator (SRC-1), and one corepressor (SMRT) in the lung of both female rats during the estrous cycle and intact males by Western blot. The rat lung presented a higher content of PR-A than that of PR-B during the estrous cycle. The highest content of both PR isoforms was observed on the day of proestrus whereas the lowest one was found on the day of estrus. In contrast, the content of ER-beta was the lowest on the day of proestrus and it increased at estrus. The content of SRC-1 and SMRT increased on the day of diestrus. SRC-1 content decreased at proestrus and estrus, while SMRT content decreased at proestrus and increased again at estrus. In the lung of adult male rats the content of PR isoforms, ER-beta and SMRT was lower than in that of females, whereas...Continue Reading

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Citations

Jan 7, 2011·Biology of Sex Differences·Rene Olivares-NavarreteZvi Schwartz
May 13, 2009·Molecular and Cellular Endocrinology·Margarita M IvanovaCarolyn M Klinge
Jul 11, 2009·Cell Biochemistry and Function·Fernanda Schäfer HackenhaarMara Silveira Benfato
Jan 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Melanie HaaseUlrich H Thome
Mar 3, 2009·Annals of the New York Academy of Sciences·Diana C Márquez-GarbánRichard J Pietras
Aug 9, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rhonda L StelckLaura S Van Winkle
Jul 31, 2021·Essays in Biochemistry·Damien A LeachCharlotte L Bevan
Jul 5, 2008·Respiratory Physiology & Neurobiology·Mary Behan, Julie M Wenninger

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