Sexual dimorphism in transmission of expression of islet autoantibodies to offspring

Diabetologia
L YuG S Eisenbarth

Abstract

To help elucidate the mode of inheritance of insulin-dependent diabetes mellitus (IDDM), we measured GAD (glutamic acid decarboxylase) autoantibodies (GAD65Ab), insulin autoantibodies (IAA), and cytoplasmic islet cell autoantibodies (ICA) in 292 sequentially screened non-diabetic offspring of patients with IDDM. The prevalence of these islet autoantibodies was higher in offspring of diabetic fathers than in offspring of diabetic mothers. The prevalences of GAD65Ab, IAA, and ICA in the offspring of diabetic fathers were 11.5%, 10.8%, and 8.1% vs 2.1%, 1.4%, and 2.8%, respectively in the offspring of diabetic mothers (p < 0.002, p < 0.001, and p = 0.06 NS). Amongst autoantibody-positive relatives the IAA and ICA levels were significantly higher in offspring of diabetic fathers than of diabetic mothers (p < 0.002 and p < 0.01, respectively). The frequencies of these autoantibodies were equal in male and female offspring. We conclude that IDDM mothers transmitted islet autoimmunity less frequently to their offspring than IDDM fathers. Given the markedly lower frequency of autoantibodies in offspring of mothers, larger sample sizes will be required to determine whether islet autoantibodies are influenced by age of IDDM onset of moth...Continue Reading

References

Jul 19, 1984·The New England Journal of Medicine·J H WarramC R Kahn

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Citations

Jan 13, 2015·Journal of Pathogens·Jana PrecechtelovaShubhada Bopegamage
Mar 20, 2003·Current Diabetes Reports·Anu-Maaria Hämäläinen, Mikael Knip
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Karin LarssonAke Lernmark
May 6, 2014·Frontiers in Neuroendocrinology·S T NgoP A McCombe
Jul 28, 2004·Diabetes Care·Jeffrey P KrischerUNKNOWN Diabetes Prevention Trial-Type 1 Study Group
May 22, 2019·Frontiers in Endocrinology·Maunil K Desai, Roberta Diaz Brinton
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·M E DamoreS DiMauro

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