Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats

Neuroscience
Tin-Tin-Win-ShweF Kimura

Abstract

We showed marked sex differences in the GABA outflow in the medial preoptic area of intact rats. To further determine the sexually dimorphic effects of estrogen on the GABA outflow, an in vivo microdialysis study was performed in gonadectomized rats 3-5 days after the estrogen- or cholesterol-priming. Dialysates and sequential blood samples (150 microl each) were simultaneously collected under freely moving conditions. Serum estradiol concentrations at 72 and 84 h after the estrogen capsule implantation were approximately 75 pg/ml in both sexes. Ovariectomized estrogen-primed (OVX+E(2)) rats showed high GABA outflow from the late night through the morning, which was significantly declined until the onset of surge like secretion of luteinizing hormone (LH) in the afternoon (N=7). Ovariectomized cholesterol-primed (OVX+C) rats consistently showed low GABA outflow and high serum LH concentration (N=8). Conversely, orchidectomized estrogen-primed (ORX+E(2)) rats showed high and episodic GABA outflow without any daily changes (N=7), which was significantly greater than orchidectomized cholesterol-primed (ORX+C; N=8) and OVX+C rats. Only OVX+E(2) rats showed significant daily changes in the GABA outflow and serum LH concentration. Fi...Continue Reading

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Citations

Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos A A PenattiLeslie P Henderson
Jul 27, 2006·Journal of Neuroendocrinology·K BarabásI M Abrahám
Oct 13, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Aleisha M Moore, Rebecca E Campbell
Oct 25, 2016·Frontiers in Cellular Neuroscience·Csaba VastaghZsolt Liposits
Dec 1, 2009·African Journal of AIDS Research : AJAR·Alexander Rödlach

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