Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Sharna D JamadarASPREE Investigator Group

Abstract

The onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of many illnesses, and sexual dimorphism influences brain anatomy, function, and cognition. Here, we examine frequency-specific connectivity in resting-state networks in a large sample (n = 406) of healthy aged adults. We quantify frequency-specific connectivity in three resting-state networks known to be implicated in age-related decline: the default mode, dorsal attention, and salience networks, using multiband functional magnetic resonance imaging. Frequency-specific connectivity was quantified in four bands: low (0.015-0.027 Hz), moderately low (0.027-0.073 Hz), moderately high (0.073-0.198 Hz), and high (0.198-0.5 Hz) frequency bands, using mean intensity and spatial extent. Differences in connectivity between the sexes in each of the three networks were examined. Each network showed the largest intensity and spatial extent at low frequencies and smallest extent at high frequencies. Males showed greater connectivity than females in the salience network. Females showed greater connectivity than males in the default mode network. Results in this healthy aged cohort are compatible with those obtained in young sample...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Apr 14, 1995·Mechanisms of Ageing and Development·J Marín
Jun 1, 1993·Journal of the American Geriatrics Society·W C WiederholtE Barrett-Connor
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Nov 5, 2003·Nature Reviews. Neuroscience·Mark D'EspositoAdam Gazzaley
Nov 6, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias L SchroeterD Yves von Cramon
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
May 12, 2006·Nature Reviews. Neuroscience·Larry Cahill
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Aug 5, 2006·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Cindy M de FriasAgneta Herlitz
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Dec 7, 2007·Neuron·Jessica R Andrews-HannaRandy L Buckner
Apr 11, 2008·Annals of the New York Academy of Sciences·Cheryl L Grady
Sep 24, 2008·Psychology and Aging·Cécile Proust-LimaJean-François Dartigues
Feb 18, 2009·Cerebral Cortex·Zarrar ShehzadMichael P Milham
Sep 29, 2009·NeuroImage·Xi-Nian ZuoMichael P Milham
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hesheng LiuRandy L Buckner
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gaolang GongAlan C Evans
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Mar 23, 2011·Human Brain Mapping·Dardo Tomasi, Nora D Volkow
Mar 29, 2011·Frontiers in Systems Neuroscience·Elena A AllenVince D Calhoun
Jun 16, 2011·Journal of Cognitive Neuroscience·Angela R LairdPeter T Fox
Jan 28, 2012·NeuroImage·David A Feinberg, Essa Yacoub
Jun 5, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexei A Maklakov, Virpi Lummaa
Oct 12, 2013·Contemporary Clinical Trials·UNKNOWN ASPREE Investigator Group
Jan 1, 2014·Neuroscience and Biobehavioral Reviews·Amber N V RuigrokJohn Suckling
Feb 18, 2014·Cerebral Cortex·Linda GeerligsMonicque M Lorist
Apr 8, 2014·Brain Connectivity·Suril R Gohel, Bharat B Biswal
Apr 15, 2014·PloS One·Klaudius KalcherEwald Moser
Aug 28, 2014·Human Brain Mapping·Lutz JänckeJürgen Hänggi
Dec 20, 2014·Human Brain Mapping·Dustin ScheinostR Todd Constable

❮ Previous
Next ❯

Citations

Sep 19, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Nicole D Anderson
Dec 24, 2019·Frontiers in Aging Neuroscience·Cindy K BarhaTeresa Liu-Ambrose
Jun 20, 2020·Journal of Neuroscience Research·Manon EddeSandra Chanraud
Apr 27, 2019·Frontiers in Neuroscience·Nina de LacyVince D Calhoun
Sep 3, 2021·Journal of Neural Transmission·Francesca TrojsiGioacchino Tedeschi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.