Sexual Dysfunctions Induced by Pregabalin

Clinical Neuropharmacology
Sherifa Ahmed Hamed

Abstract

Pregabalin (PGB) is a gabapentinoid (ie, GABA analog), which has been Food and Drug Administration-approved for treatment of partial epilepsy in adults and neuropathic pain. It also has off-label uses for the treatment of generalized anxiety disorders, fibromyalgia, and tension headache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin). This study aimed to determine the frequency and types of SDs induced by PGB and the temporal relation to its use. We presented case series of patients (n = 75) treated with PGB for different indications (sciatica, atypical facial pain, chronic tension headache, transformed migraine, fibromyalgia, and generalized anxiety disorder and developed different aspects of SDs). In this case series, SDs were noticed with PGB in 41.33% (n = 31) (men, 13 [50%]; women, 18 [36.73%]), which included erectile dysfunction (n = 16, 51.61%), anorgasmia (n = 10, 32.26%), and loss of libido (n = 11, 35.48%). Sexual dysfunctions occurred within weeks after the use of PGB and were not dose related. They occurred with low therapeutic PGB doses (50-100 mg/d). Discontinuation of PGB res...Continue Reading

References

Aug 1, 1996·The American Journal of Psychiatry·D R Rubinow, P J Schmidt
Apr 3, 1999·Medicinal Research Reviews·J S Bryans, D J Wustrow
Jun 9, 1999·The American Journal of Psychiatry·L A Labbate, R N Rubey
Dec 22, 1999·Neurology·J D Clark, J Elliott
Mar 23, 2000·Southern Medical Journal·A M HusainR A Radtke
Jun 1, 2000·Journal of Clinical Psychopharmacology·G E Brannon, P D Rolland
Mar 21, 2001·Bipolar Disorders·J M Montes, L Ferrando
Jul 2, 2002·The American Journal of Psychiatry·Arthur C Grant, Hyunjue Oh
Aug 9, 2002·European Journal of Pharmacology·Johannes A van HooftWytse J Wadman
Mar 26, 2003·Psychoneuroendocrinology·H KnegteringR J van den Bosch
Mar 27, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Rodney Drabkin, Laura Calhoun
Feb 14, 2004·International Journal of Impotence Research·P PerimenisG Barbalias
Oct 27, 2004·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Pierre Chue
Jun 18, 2005·Nature Reviews. Drug Discovery·Robert H Dworkin, Peter Kirkpatrick
Nov 8, 2006·Acta Psychiatrica Scandinavica·U WernekeD Bhugra
Jul 6, 2007·Expert Review of Neurotherapeutics·Borwin BandelowTeresa Leon
Jan 12, 2008·BMJ : British Medical Journal·Elizabeth Loder, Paul Rizzoli
Jan 16, 2008·The Neurologist·Anjali Dalal, Linqiu Zhou
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N AttalT Nurmikko
May 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L BendtsenUNKNOWN EFNS
Apr 12, 2011·The Journal of Headache and Pain·Raffaella PizzolatoGiuliano Sette
May 24, 2011·The American Journal of Geriatric Pharmacotherapy·Michael D PerloffJames A Otis
May 27, 2011·Epilepsy & Behavior : E&B·Kenneth R Kaufman, Peter J Struck
Aug 3, 2013·Epileptic Disorders : International Epilepsy Journal with Videotape·Rocco Salvatore CalabròPlacido Bramanti
Aug 7, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael I BennettMeryem Nimour
Mar 13, 2014·The Journal of Sexual Medicine·Mehtap BozkurtIsa Ozbey
Apr 17, 2014·JAMA : the Journal of the American Medical Association·Daniel J Clauw
Apr 14, 2016·Pharmacology Research & Perspectives·Ryan Patel, Anthony H Dickenson
Jun 15, 2017·The New England Journal of Medicine·Christopher G MaherStephanie Mathieson
Jun 16, 2017·The New England Journal of Medicine·Eberval G Figueiredo, Manoel J Teixeira

❮ Previous
Next ❯

Citations

May 3, 2019·Current Pain and Headache Reports·Omar ViswanathAlan D Kaye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Pharmacology in Drug Development
H Karl Greenblatt, David J Greenblatt
Epileptic Disorders : International Epilepsy Journal with Videotape
Rocco Salvatore CalabròPlacido Bramanti
American Family Physician
Michael J Arnold
© 2022 Meta ULC. All rights reserved