Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones.

PloS One
Benedetta LeunerE Gould

Abstract

Aversive stressful experiences are typically associated with increased anxiety and a predisposition to develop mood disorders. Negative stress also suppresses adult neurogenesis and restricts dendritic architecture in the hippocampus, a brain region associated with anxiety regulation. The effects of aversive stress on hippocampal structure and function have been linked to stress-induced elevations in glucocorticoids. Normalizing corticosterone levels prevents some of the deleterious consequences of stress, including increased anxiety and suppressed structural plasticity in the hippocampus. Here we examined whether a rewarding stressor, namely sexual experience, also adversely affects hippocampal structure and function in adult rats. Adult male rats were exposed to a sexually-receptive female once (acute) or once daily for 14 consecutive days (chronic) and levels of circulating glucocorticoids were measured. Separate cohorts of sexually experienced rats were injected with the thymidine analog bromodeoxyuridine in order to measure cell proliferation and neurogenesis in the hippocampus. In addition, brains were processed using Golgi impregnation to assess the effects of sexual experience on dendritic spines and dendritic complexit...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Dec 22, 1999·Physiology & Behavior·G Rodríguez-ManzoA Fernández-Guasti
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Jun 4, 2002·Nature Reviews. Neuroscience·Jeansok J Kim, David M Diamond
Oct 9, 2002·Behavioral Neuroscience·D M BannermanJ N P Rawlins
Aug 2, 2003·Biological Psychiatry·Bruce S McEwen
Nov 22, 1963·Science·A G HUNDT, D PREMACK
Jun 15, 2004·Nature Neuroscience·Günter U HöglingerEtienne C Hirsch
Oct 4, 2005·Hormones and Behavior·H Bonilla-JaimeS Retana-Márquez
Mar 15, 2006·Nature Neuroscience·Alexis M StranahanElizabeth Gould
Jul 4, 2006·Behavioral and Cognitive Neuroscience Reviews·Cheryl D Conrad
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
May 15, 2007·Hormones and Behavior·Elaine M Hull, Juan M Dominguez
May 22, 2007·Nature Reviews. Neuroscience·Elizabeth Gould
Jun 5, 2007·Physiology & Behavior·Kassandra L Edinger, Cheryl A Frye
Jun 15, 2007·Physiology & Behavior·Stefan BrenéMartin Werme
Jul 20, 2007·Hippocampus·Alexis M StranahanElizabeth Gould
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Oct 6, 2007·Journal of Applied Physiology·David A BrownRussell L Moore
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Martin Waldherr, Inga D Neumann
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rupshi Mitra, Robert M Sapolsky
Dec 25, 2008·ILAR Journal·Raúl G Paredes
Mar 4, 2009·Molecular Psychiatry·J-M RevestD N Abrous
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman

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Citations

Jul 18, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Elizabeth A Schoenfeld, Timothy J Loving
Jul 14, 2012·AJNR. American Journal of Neuroradiology·M Castillo
Feb 16, 2016·Frontiers in Neuroendocrinology·Melissa M Holmes
Mar 13, 2014·Neuroscience·D E PeragineM M Holmes
May 21, 2013·Frontiers in Neuroendocrinology·Mei-Fang Cheng
Feb 18, 2016·Neural Plasticity·Alessandra Aparecida MarquesGisele Pereira Dias
Jan 8, 2016·Brain Research·Bruce S McEwen
Apr 28, 2012·General and Comparative Endocrinology·Jennifer A Howell-StephensRachel M Santymire
Nov 22, 2011·Neuroscience Research·Hirotaka Sakamoto
Nov 22, 2011·Ageing Research Reviews·Marlena Wosiski-Kuhn, Alexis M Stranahan
Jun 1, 2011·Behavioural Brain Research·Erica R GlasperElizabeth Gould
Mar 15, 2016·Frontiers in Neuroscience·Nancy M UndaRaúl G Paredes
Jul 19, 2015·Neurobiology of Learning and Memory·Erica R GlasperElizabeth Gould
Mar 15, 2016·ACS Chemical Neuroscience·Jorge ValeroAmanda Sierra
Oct 9, 2012·The European Journal of Neuroscience·Miriam S NokiaTracey J Shors
Mar 22, 2016·Frontiers in Neuroendocrinology·Maya OpendakElizabeth Gould
Feb 5, 2016·The Journal of Physiology·Miriam S NokiaHeikki Kainulainen
Sep 26, 2015·Nature Neuroscience·Bruce S McEwenCarla Nasca
Apr 18, 2016·Frontiers in Neuroendocrinology·Tracey J Shors, Emma M Millon
Mar 31, 2015·Frontiers in Physiology·Yassemi Koutmani, Katia P Karalis
Mar 21, 2015·Nature Reviews. Neuroscience·Martin EgelandCarmine M Pariante
Feb 1, 2014·Social Neuroscience·Skyler J MooneyMelissa M Holmes

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