Sexual experience reduces neuronal activity in the central part of the medial preoptic nucleus in male rats during sexual behavior

Neuroscience Letters
Shohei YamaguchiShinji Tsukahara

Abstract

The medial preoptic area (MPN) plays an important role in the control of male sexual behavior. In rats, the central part of the MPN (MPNc) is sexually dimorphic and contains a sexually dimorphic nucleus composed of neurons expressing calbindin-D28 K (CALB-SDN). Although the functions of the MPNc are not well understood, surgical destruction of the MPNc adversely affects the performance of sexual behavior in sexually naive males, but not in sexually experienced males, supporting the notion that the MPNc changes functionally with sexual experience. In this study, we aimed to determine the effects of sexual experience on the neuronal activity of the MPNc and CALB-SDN. Sexual behavior in sexually inexperienced males that had no experience of ejaculation, and experienced males that had ejaculated once was observed. After they displayed sexual behavior, the brains were sampled, and immunohistochemical analysis of c-Fos, a neuronal activity marker, in the MPNc and CALB-SDN was performed. The numbers of c-Fos-immunopositive cells with or without calbindin-D28K-immunoreactivity increased significantly in the MPNc and CALB-SDN following ejaculation in both sexually inexperienced and experienced males, although the numbers did not change ...Continue Reading

Citations

Aug 28, 2020·Frontiers in Neuroscience·Shinji Tsukahara, Masahiro Morishita
Oct 12, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Polina A VishnyakovaPetr M Masliukov
Apr 20, 2021·Frontiers in Neuroscience·Yousuke Tsuneoka, Hiromasa Funato
Mar 6, 2019·Journal of Neuroscience Methods·Mario Buenrostro-JáureguiLuis Miguel Rodríguez-Serrano

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