Sexual function and depressive symptoms in young women with elevated macroprolactin content: a pilot study

Endocrine
R KrysiakB Okopień

Abstract

Elevated prolactin levels seem to be associated with impaired sexuality. The clinical significance of macroprolactinemia, associated with the predominance of high molecular mass circulating forms of prolactin, is still poorly understood. This study was aimed at investigating sexual function in young women with macroprolactinemia. The study enrolled 14 young women with macroprolactinemia, 14 with increased monomeric prolactin levels, as well as 14 age- and weight-matched healthy women. All patients completed a questionnaire evaluating female sexual function (Female Sexual Function Index-FSFI), as well as a questionnaire assessing the presence and severity of depressive symptoms (Beck Depression Inventory Second Edition-BDI-II). Apart from total prolactin levels and macroprolactin content, circulating levels of thyrotropin, total testosterone, and 17-β estradiol were also measured. Patients with elevated monomeric prolactin levels had a lower total FSFI score, as well as lower scores for all domains: sexual desire, sexual arousal, lubrication, orgasm, sexual satisfaction, and dyspareunia. These scores correlated with total and monomeric prolactin levels. In turn, women with macroprolactinemia were characterized by a lower score f...Continue Reading

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Citations

Aug 22, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Robert KrysiakBogusław Okopień
May 11, 2018·American Journal of Therapeutics·Robert Krysiak, Bogusław Okopień
Jul 18, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Helen S PereiraAlice H Violante
May 3, 2019·Current Opinion in Obstetrics & Gynecology·Sydney Chang, Alan B Copperman
Jul 13, 2020·Clinical Endocrinology·Robert KrysiakBogusław Okopień
Oct 1, 2018·Endocrine·Amanpreet Kaur KalsiJ B Sharma

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
gel filtration
receiving
pharmacotherapy

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