Sexual incentive motivation in old male rats: the effects of sildenafil and a compound (Impaza) stimulating endothelial NO synthase

Pharmacology, Biochemistry, and Behavior
X Chu, Anders Agmo

Abstract

Several proerectile drugs act on the nitric oxide-cyclic guanosine monophosphate pathway, which is known to influence rat copulatory behavior. In the present study we evaluated the effects of two proerectile compounds, one (Impaza) acting on endothelial nitric oxide synthase, and the other (sildenafil) on phosphodiesterase 5, on sexual incentive motivation in male rats displaying a spontaneously low level of motivation and copulatory behavior. About 20 months old male Fisher 344 rats were tested in a procedure for evaluating the intensity of sexual incentive motivation and in standard mating tests. For comparison, a group of young (about 4 months) Fisher 344 males was tested in parallel. This group did not receive any drug treatment. Impaza was administered in two doses, daily for 28 days, and sildenafil was given at a dose of 3 mg/kg twice a week during 28 days. Tests for sexual incentive motivation and copulatory behavior were performed immediately before the beginning of drug treatments, and on days 7, 14 and 28 of treatment. All treatment groups displayed a very low level of copulatory behavior and a sexually receptive female was not a more powerful incentive than another male at the tests performed before and on days 7 and...Continue Reading

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Citations

Jan 16, 2009·The Journal of Sexual Medicine·Hesham Abdul AzizYvonne Tze Fung Tan
Sep 8, 2010·Hormones and Behavior·Anders Agmo
Oct 6, 2009·Physiology & Behavior·Carmen Agustín-PavónEnrique Lanuza
May 26, 2009·Behavioural Brain Research·Tathiana A AlvarengaSergio Tufik
Nov 11, 2008·Physiology & Behavior·Ann S ClarkFay A Guarraci
Jan 9, 2013·Physiology & Behavior·Rosa Angélica LucioAnders Ågmo
May 2, 2016·Pharmacology, Biochemistry, and Behavior·Marcia M D FerrazMarcos R Ferraz
Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Vladimir RafalskyOleg Epstein
Jan 24, 2012·Bulletin of Experimental Biology and Medicine·E S ZhavbertO I Epstein
Jul 18, 2018·Dose-response : a Publication of International Hormesis Society·Elena V KardashOleg I Epstein

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