Sexual interactions with unfamiliar females reduce hippocampal neurogenesis among adult male rats

Neuroscience
Mark D SpritzerLeanne M Shulman

Abstract

Recent experiments have shown that sexual interactions prior to cell proliferation cause an increase in neurogenesis in adult male rats. Because adult neurogenesis is critical for some forms of memory, we hypothesized that sexually induced changes in neurogenesis may be involved in mate recognition. Sexually naive adult male rats were either exposed repeatedly to the same sexual partner (familiar group) or to a series of novel sexual partners (unfamiliar group), while control males never engaged in sexual interactions. Ovariectomized female rats were induced into estrus every four days. Males were given two injections of 5-bromo-2'-deoxyuridine (BrdU) (200mg/kg) to label proliferating cells, and the first sexual interactions occurred three days later. Males in the familiar and unfamiliar groups engaged in four, 30-min sexual interactions at four-day intervals, and brain tissue was collected the day after the last sexual interaction. Immunohistochemistry followed by microscopy was used to quantify BrdU-labeled cells. Sexual interactions with unfamiliar females caused a significant reduction in neurogenesis in the dentate gyrus compared to males that interacted with familiar females and compared to the control group. The familiar...Continue Reading

References

Aug 1, 1977·Animal Behaviour·R J BlanchardM J Kelley
Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·N V Watson, B B Gorzalka
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 1, 1974·Hormones and Behavior·H SzechtmanE S Redgate
Jul 1, 1996·Physiology & Behavior·H MaaswinkelB M Spruijt
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
May 24, 2000·Neuroscience Letters·P AmbroginiP Del Grande
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Apr 27, 2002·Nature Neuroscience·Norbert J FortinHoward B Eichenbaum
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Dec 6, 2003·The European Journal of Neuroscience·Sebastian Jessberger, Gerd Kempermann
Mar 31, 2004·Neuroscience Letters·Patrizia AmbroginiRiccardo Cuppini
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yevgenia Kozorovitskiy, Elizabeth Gould
Nov 25, 2004·Brain Research Bulletin·Christel WestenbroekGert J Ter Horst
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon
Jun 22, 2005·Neuroscience Letters·Heather Y McDonald, J Martin Wojtowicz
Oct 4, 2005·Hormones and Behavior·H Bonilla-JaimeS Retana-Márquez
Oct 11, 2005·Neurobiology of Learning and Memory·Amanda S SquiresCarolyn W Harley
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wen-Sung LaiRobert E Johnston
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Jan 18, 2006·Hippocampus·Christian Mirescu, Elizabeth Gould
Feb 28, 2006·Biological Psychiatry·Mounira BanasrAnnie Daszuta
Mar 15, 2006·Nature Neuroscience·Alexis M StranahanElizabeth Gould
May 30, 2006·Nature Neuroscience·James B AimoneFred H Gage
Sep 12, 2006·Neuroscience·P MohapelH Frielingsdorf
Dec 7, 2006·Developmental Neuroscience·Helen ScharfmanDaniel McCloskey
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael D SaxeRené Hen
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rosanne M ThomasDaniel A Peterson
Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Friederike Klempin, Gerd Kempermann
May 15, 2007·Hormones and Behavior·Elaine M Hull, Juan M Dominguez

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Citations

Mar 22, 2016·Frontiers in Neuroendocrinology·Maya OpendakElizabeth Gould
Apr 18, 2016·Frontiers in Neuroendocrinology·Tracey J Shors, Emma M Millon
May 17, 2018·Archives of Sexual Behavior·Mark S Allen
Apr 9, 2020·Frontiers in Neuroscience·Wendy PortilloRaúl G Paredes

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