Sexual responses of the male rat medial preoptic area and medial amygdala to estrogen II: site specific effects of selective estrogenic drugs

Hormones and Behavior
Nancy V RussellAndrew N Clancy

Abstract

In the medial preoptic area (MPO) and medial amygdala (MEA), estradiol (E(2)) aromatized from testosterone (T) may act via either estrogen receptor (ER) α or ERβ to mediate mating in male rats. We tested the hypothesis that, in the MPO, ERα exclusively mediates sexual responses to E(2) by monitoring mating in four groups of castrated male rats administered dihydrotestosterone (DHT) subcutaneously and MPO implants delivering either: cholesterol, E(2), propyl pyrazole triol (PPT, ERα-agonist) or diarylpropionitrile (DPN, ER β-agonist); a fifth group of intact males served as DPN toxicity control, receiving DPN MPO implants. In a follow-up study, either 1-methyl-4-phenyl pyridinium (MPP, ERα-antagonist) or blank MPO cannulae were implanted in castrated male rats receiving T subcutaneously, whereas intact MPP toxicity controls received MPP MEA implants. PPT or E(2) MPO implants maintained mating, but cholesterol or DPN MPO implants did not. Moreover, MPP MPO implants interfered with T reinstatement of mating suggesting that, in the MPO, ERα is necessary and sufficient for mating in androgen-maintained male rats and ERβ is not sufficient. Because it is unknown which ER subtype(s) mediate sexual responses of the MEA to E(2), we exami...Continue Reading

References

Mar 28, 1975·Brain Research·V S Harris, B D Sachs
Sep 26, 1975·Science·F MacridesS Dalterio
Mar 15, 1990·Cancer·A LiptonR J Santen
Feb 1, 1988·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S AndoF Dessi-Fulgheri
Apr 15, 1986·The Journal of Comparative Neurology·R B Simerly, L W Swanson
Sep 1, 1973·Hormones and Behavior·P Södersten
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E V JensenE R DeSombre
Jun 1, 1969·Endocrinology·J M Davidson
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Pfaff
Aug 31, 2000·Hormones and Behavior·A N ClancyR P Michael
Jun 20, 2001·The Journal of Comparative Neurology·P J Shughrue, I Merchenthaler
Jun 6, 2003·Hormones and Behavior·Béatrice GrécoJeffrey D Blaustein
Jul 2, 2003·Physiology & Behavior·Gloria G HuddlestonAndrew N Clancy
Jul 8, 2003·Neuroendocrinology·Takahiro MatsumotoNobuhiro Harada
May 8, 2004·Endocrinology·Victor V ChabanPaul Micevych
May 3, 2005·Steroids·Albert J Evinger, Ellis R Levin
Nov 30, 2006·Pharmacological Reviews·Karin Dahlman-WrightJan-Ake Gustafsson
Feb 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gloria G HuddlestonAndrew N Clancy
Jul 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Charles F Roselli

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Citations

Nov 12, 2013·Hormones and Behavior·Panida LoutchanwootHubertus Jarry
Aug 6, 2013·Frontiers in Neuroendocrinology·Aras Petrulis
Jul 23, 2013·Frontiers in Neuroendocrinology·Michael J Baum, Julie Bakker
May 16, 2014·Journal of Neuroendocrinology·E Antonio-Cabrera, R G Paredes
Dec 14, 2019·The European Journal of Neuroscience·Badr KhbouzCharlotte A Cornil
Oct 24, 2021·Frontiers in Neuroendocrinology·Arnaud JeanHélène Hardin-Pouzet

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