Sexual responses of the male rat medial preoptic area and medial amygdala to estrogen I: site specific suppression of estrogen receptor alpha

Hormones and Behavior
Jacquelyn C PaisleyAndrew N Clancy

Abstract

Male rat copulation is mediated by estrogen-sensitive neurons in the medial preoptic area (MPO) and medial amygdala (MEA); however, the mechanisms through which estradiol (E(2)) acts are not fully understood. We hypothesized that E(2) acts through estrogen receptor α (ERα) in the MPO and MEA to promote male mating behavior. Antisense oligodeoxynucleotides (AS-ODN) complementary to ERα mRNA were bilaterally infused via minipumps into either brain area to block the synthesis of ERα, which we predicted would reduce mating. Western blot analysis and immunocytochemistry revealed a knockdown of ERα expression in each brain region; however, compared to saline controls, males receiving AS-ODN to the MPO showed significant reductions in all components of mating, whereas males receiving AS-ODN to the MEA continued to mate normally. These results suggest that E(2) acts differently in these brain regions to promote the expression of male rat sexual behavior and that ERα in the MPO, but not in the MEA, promotes mating.

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Citations

Nov 12, 2013·Hormones and Behavior·Panida LoutchanwootHubertus Jarry
Aug 6, 2013·Frontiers in Neuroendocrinology·Aras Petrulis
Jul 23, 2013·Frontiers in Neuroendocrinology·Michael J Baum, Julie Bakker
May 16, 2014·Journal of Neuroendocrinology·E Antonio-Cabrera, R G Paredes
Jun 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro SanoSonoko Ogawa
Aug 28, 2016·Sexual Medicine Reviews·Elisa Ventura-Aquino, Raúl G Paredes
Dec 14, 2019·The European Journal of Neuroscience·Badr KhbouzCharlotte A Cornil

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