Sexual selection and inbreeding: Two efficient ways to limit the accumulation of deleterious mutations

Evolution Letters
Elsa NoëlP David

Abstract

Theory and empirical data showed that two processes can boost selection against deleterious mutations, thus facilitating the purging of the mutation load: inbreeding, by exposing recessive deleterious alleles to selection in homozygous form, and sexual selection, by enhancing the relative reproductive success of males with small mutation loads. These processes tend to be mutually exclusive because sexual selection is reduced under mating systems that promote inbreeding, such as self-fertilization in hermaphrodites. We estimated the relative efficiency of inbreeding and sexual selection at purging the genetic load, using 50 generations of experimental evolution, in a hermaphroditic snail (Physa acuta). To this end, we generated lines that were exposed to various intensities of inbreeding, sexual selection (on the male function), and nonsexual selection (on the female function). We measured how these regimes affected the mutation load, quantified through the survival of outcrossed and selfed juveniles. We found that juvenile survival strongly decreased in outbred lines with reduced male selection, but not when female selection was relaxed, showing that male-specific sexual selection does purge deleterious mutations. However, in l...Continue Reading

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Citations

Jul 7, 2019·G3 : Genes - Genomes - Genetics·Ivo M CheloHenrique Teotónio
Mar 30, 2021·Trends in Ecology & Evolution·Jeanne TonnabelMathilde Dufay
Aug 18, 2021·Heredity·Noelia Pérez-PereiraArmando Caballero

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