Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women

Endocrine Connections
María José GómoraCarmen Méndez

Abstract

The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER- PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium sh...Continue Reading

References

May 20, 1978·Lancet·V BeralC Chilvers
Sep 21, 2001·Medical Education·B Jolly
Nov 19, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Russell VangBrigitte M Ronnett
Apr 2, 2008·Cancer Science·Hiroaki ItamochiNaoki Terakawa
Feb 2, 2012·PloS One·Paul H van der HorstLeen J Blok
Feb 11, 2012·Virchows Archiv : an International Journal of Pathology·Jaime Prat
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Prat
Dec 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dong ZhaoJing Sun
Jan 12, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth M PooleShelley S Tworoger
May 15, 2013·The World Allergy Organization Journal·Anneke C Kai, Carsten Flohr
Feb 22, 2014·Gynecologic Oncology·Pi-Lin SungUNKNOWN Task Force on Systematic Review and Meta-analysis of Ovarian Cancer
Jul 30, 2014·Cancer Prevention Research·Amber A BokhariViqar Syed
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Nov 5, 2014·Coronary Artery Disease·Yasushi Matsuzawa, Amir Lerman
Jun 28, 2015·Gynecologic Oncology·Michel van KruchtenAnna Reyners
Oct 27, 2015·Translational Oncology·Jenny-Maria JönssonIngrid Hedenfalk
Jan 4, 2017·Steroids·Luiz Gustavo de Almeida ChuffaFábio Rodrigues Ferreira Seiva
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Luis Z BlancoRobert J Kurman
Aug 23, 2017·Steroids·Francisca Plaza-ParrochiaMargarita Vega
Oct 28, 2017·Cancer Treatment Reviews·Debora BasileFabio Puglisi
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Aug 14, 2019·Oncogenesis·Marisol Salgado-AlbarránErnesto Soto-Reyes
Aug 14, 2020·Cancers·Laura CaraviaSilviu Cristian Voinea
Feb 10, 2019·Journal of Ovarian Research·Enrique PederneraCarmen Mendez
Mar 6, 2021·Environmental Science and Pollution Research International·Nadeem Ghani KhanShama Prasada Kabekkodu

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.