Sexually conditioned incentives: attenuation of motivational impact during dopamine receptor antagonism

Pharmacology, Biochemistry, and Behavior
Hassan H Lopez, Aaron Ettenberg

Abstract

The motivational impact of sexually conditioned incentives was examined in two experiments. In Experiment 1, male Long-Evans rats copulated to ejaculation in the presence of one of two scents (orange or almond extract) on five separate occasions. On alternating days, subjects spent an equal amount of time in social isolation with the opposing scent. Following the 10-day conditioning regimen, subjects ran more rapidly down an operant runway toward a goalbox containing the sex-paired scent (CS+) compared to trials on which the isolation-paired scent (CS-) or no scent was provided. In Experiment 2, comparably conditioned male rats were first given a baseline runway trial with an unscented goalbox. The following day, subjects were pretreated with one of four doses of haloperidol (0.0, 0.075, 0.15, or 0.30 mg/kg i.p.) 45 min prior to being tested in the runway for their motivation to approach either the CS+ or CS- scents. Control subjects given vehicle injections performed comparably to subjects from Experiment 1, taking significantly less time to approach the CS+ than an unscented goalbox. This decrease in run latency was not observed in subjects within the 0.075 and 0.15 mg/kg haloperidol groups. Subjects in the 0.30 mg/kg haloper...Continue Reading

Citations

Feb 3, 2016·Psychopharmacology·Mirte BromStephanie Both
Feb 8, 2005·Psychopharmacology·A E KudwaE F Rissman
Sep 14, 2012·Journal of Pharmacological Sciences·Hidenori SagaraYutaka Gomita
May 26, 2018·The European Journal of Neuroscience·Valeria Violante-SoriaGabriela Rodríguez-Manzo
Feb 2, 2013·Endocrinology·Margaret R Bell, Cheryl L Sisk
Feb 3, 2015·Shinrigaku kenkyu : The Japanese journal of psychology·Kazuma Mori, Makoto Iwanaga
Nov 26, 2009·Pharmacology, Biochemistry, and Behavior·Hassan H LópezBenjamin Chadwick
Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Mirte BromPhilip Spinhoven

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