Sexually dimorphic alterations of brain cortical dominance in rats prenatally exposed to TCDD

Journal of Applied Toxicology : JAT
Grazyna ZarebaBernard Weiss

Abstract

Sexually dimorphic patterns of cortical lateralization are documented extensively in both human and animal brains. Male rats tend to exhibit pronounced right hemisphere dominance compared with females, whereas females typically exhibit more diffuse lateralization patterns and greater left hemisphere bias compared with males. Prenatal TCDD (2,3,7,8 tetrachlorodibenzo-p-dioxin) exposure produces demasculinization of male offspring sexual behavior. In previous studies, we showed a reversal of cortical dominance in rats after prenatal TCDD exposure on gestational day 18 (GD 18). The current study aimed to determine the nature of changes observed in rats exposed to TCDD on GD 8. In addition, locomotor activity was measured in male and female offspring on postnatal day (PND) 30, 60 and 90. Pregnant females were given, via gavage, a single dose of 0, 20, 60 or 180 ng kg(-1) TCDD on GD 8. Cortical depth measurements were taken in selected brain regions in offspring 3 months old that had been exposed to the 180 ng kg(-1) dose. Areas 2, 3, 17, 18a and 39 at bregmas -1.8, -3.8 and -5.8 were analyzed by quantifying digitized, enhanced images produced by a photomicroscope fitted with a special color camera. In both male and female offspring...Continue Reading

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Citations

Dec 1, 2003·Environmental Toxicology and Pharmacology·Hideaki YamaguchiKazuo Ryoyama
Mar 31, 2005·The American Psychologist·Susan M KogerBernard Weiss
Feb 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·C A Wilson, D C Davies
Jun 9, 2007·Molecular and Cellular Endocrinology·Junko TanakaHideko Sone
Mar 8, 2002·Environmental Health Perspectives·Rieko HojoBernard Weiss
Sep 17, 2005·Journal of Applied Toxicology : JAT·Rieko HojoBernard Weiss
May 13, 2006·Endocrinology·Sandra L PetersenEdward D Hudgens

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