Sexually dimorphic brain volume interaction in college-aged binge drinkers

NeuroImage. Clinical
Timo L KvammeValerie Voon

Abstract

Binge consumption of alcohol is a major societal problem associated with important cognitive, physiological and neurotoxic consequences. Converging evidence highlights the need to assess binge drinking (BD) and its effects on the developing brain while taking into account gender differences. Here, we compared the brain volumetric differences between genders in college-aged binge drinkers and healthy volunteers. T1-weighted magnetic resonance imaging (MRI) images of 30 binge drinkers (18 males) and 46 matched healthy volunteers (23 males) were examined using voxel-based morphometry. The anatomical scans were covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Whole brain voxel-wise group comparisons were performed using a cluster extent threshold correction. Several large clusters qualified with group-by-gender interactions were observed in prefrontal, striatal and medial temporal areas, whereby BD females had more volume than non-BD females, while males showed the inverse pattern of decreased volume in BD males and increased volume in non-BD males. AUDIT scores negatively correlated with volume in the right superior frontal cortex and precentral gyrus. These findings dovetail with previous studies reporting ...Continue Reading

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Citations

Jan 21, 2017·Addiction Biology·Laurel S MorrisValerie Voon
Jun 24, 2017·Frontiers in Psychology·María-Teresa Cortés-TomásMaría-Dolores Sancerni-Beitia
Apr 19, 2017·Addiction Biology·Nuria DoñamayorValerie Voon
Sep 30, 2017·Frontiers in Behavioral Neuroscience·Eduardo López-CanedaSocorro Rodríguez Holguín
Mar 2, 2017·Addiction Biology·Laurel S MorrisUNKNOWN ICCAM Consortium
Mar 9, 2021·Brain Plasticity·Ibdanelo CortezJ Leigh Leasure

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Software Mentioned

Statistical Parametric Mapping ( SPM8
ImCalc
MRIcro
DARTEL
R
AUDIT
ggplot2

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