Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads

Gene Expression Patterns : GEP
Hector Rodriguez-MagadánHilda Lomelí

Abstract

Members of the PIAS (protein inhibitor of activated STAT) family perform essential functions in modulating the activity of transcriptional regulators. Zimp7 and Zimp10 are two proteins that together form a subfamily of the PIAS. Like the other members of this family, they contain the zinc-binding SP-RING/Miz domain, which confers SUMO-conjugating activity. Both proteins have been shown to stimulate androgen receptor-mediated transcription. Previously, we reported that both Zimp7 and Zimp10 genes are extensively expressed and dynamically regulated in the developing mouse embryo. In this work, we investigated the expression of these genes during gonadal development. We found that their expression is sex-specific. Both genes initiate their transcription at early stages in the embryonic male gonad, reaching their peak at 13.5days post coitum, which coincides with the process of sex-specific germ cell mitotic arrest. Zimp7 is expressed in germ cells of the embryonic gonad and the adult testis. Immunofluorescence of spermatogenic cells revealed that Zimp7 protein localizes to nuclear territories in meiotic spermatocytes, including the XY bodies. On the other hand, Zimp10 is found in somatic cells, outside the testis cords and ceases ...Continue Reading

References

May 9, 1991·Nature·P KoopmanR Lovell-Badge
Oct 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nikolaus SchultzDavid L Garbers
May 4, 2004·Experimental Cell Research·Mary Ann Handel
Sep 7, 2004·Chromosoma·Richard S RogersMichael J Matunis
Jun 17, 2006·The Journal of Biological Chemistry·Xiaomeng LiZijie Sun
Jul 25, 2006·Nuclear Receptor Signaling·Jason Beliakoff, Zijie Sun
Jan 24, 2007·Physiological Reviews·Dagmar WilhelmPeter Koopman
Nov 21, 2007·Stem Cells·Patrick S WesternAndrew H Sinclair
Dec 7, 2007·Gene Expression Patterns : GEP·Hector Rodriguez-MagadánHilda Lomelí
Jun 28, 2008·Cell Cycle·Yoshimitsu TakahashiYoshiko Kikuchi
Jul 8, 2008·Developmental Biology·Sophie La SalleMary Ann Handel
Feb 7, 2009·Seminars in Reproductive Medicine·Jonah Cool, Blanche Capel

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Citations

Oct 14, 2010·Cell Biochemistry and Function·Niina TanakaHisato Saitoh
Apr 21, 2020·Biochemical Society Transactions·Ana TalamilloRosa Barrio

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