Sexually transmitted diseases among users of erectile dysfunction drugs: analysis of claims data.

Annals of Internal Medicine
Anupam B JenaYang Lu

Abstract

Pharmacologic treatments for erectile dysfunction (ED) have gained popularity among middle-aged and older men. Increased sexual activity among those who use these drugs raises concerns about sexually transmitted diseases (STDs). To examine the rates of STDs in men who use and do not use ED drugs. Retrospective cohort study. Database of claims from 1997 to 2006 for 1,410,806 men older than age 40 years with private, employer-based insurance from 44 large companies. 33,968 men with at least 1 filled prescription for an ED drug and 1,376,838 patients with no prescription. STD prevalence among users and nonusers of ED drugs. Users of ED drugs had higher rates of STDs than nonusers the year before initiating ED drug therapy (214 vs. 106 annually per 100,000 persons; P = 0.003) and the year after (105 vs. 65; P = 0.004). After adjustment for age and other comorbid conditions, users of ED drugs had an odds ratio (OR) for an STD of 2.80 (95% CI, 2.10 to 3.75) in the year before initiating drug therapy; the OR was 2.65 (CI, 1.84 to 3.81) in the year after. These differences were largely due to infections with HIV. The OR for HIV infection was 3.32 (CI, 2.38 to 4.36) in the year before and 3.19 (CI, 2.11 to 4.83) in the year after an ED ...Continue Reading

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