Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort

Open Forum Infectious Diseases
Jose LucarDC Cohort Executive Committee

Abstract

Washington, DC, has one of the highest rates of HIV infection in the United States. Sexual intercourse is the leading mode of HIV transmission, and sexually transmitted infections (STIs) are a risk factor for HIV acquisition and transmission. We evaluated the incidence and demographic factors associated with chlamydia, gonorrhea, and syphilis among HIV-infected persons enrolled at 13 DC Cohort sites from 2011 to 2015. Using Poisson regression, we assessed covariates of risk for incident STIs. We also examined HIV viral loads (VLs) at the time of STI diagnosis as a proxy for HIV transmission risk. Six point seven percent (451/6672) developed an incident STI during a median follow-up of 32.5 months (4% chlamydia, 3% gonorrhea, 2% syphilis); 30% of participants had 2 or more STI episodes. The incidence rate of any STIs was 3.8 cases per 100 person-years (95% confidence interval [CI], 3.5-4.1); age 18-34 years, 10.8 (95% CI, 9.7-12.0); transgender women, 9.9 (95% CI, 6.9-14.0); Hispanics, 9.2 (95% CI, 7.2-11.8); and men who have sex with men (MSM), 7.7 (95% CI, 7.1-8.4). Multivariate Poisson regression showed younger age, Hispanic ethnicity, MSM risk, and higher nadir CD4 counts to be strongly associated with STIs. Among those with...Continue Reading

References

Feb 28, 2002·American Journal of Public Health·Mitchell H KatzWilliam McFarland
Jun 10, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Emily J ErbeldingAnne M Rompalo
Apr 4, 2006·Sexually Transmitted Infections·S J ReynoldsS M Mehendale
Jun 30, 2010·Sexually Transmitted Diseases·Karen W HooverUNKNOWN Evaluation Group for Adherence to STD and Hepatitis Screening
Apr 8, 2011·Science Translational Medicine·Jared M BaetenUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Apr 21, 2012·The Journal of Infectious Diseases·Myron S Cohen
May 18, 2012·Sexually Transmitted Diseases·Anuradha GanesanUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
May 9, 2014·AIDS·Pragna PatelJonathan Mermin
Jun 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marc M SolomonUNKNOWN iPrEx Study Team
May 21, 2015·Journal of the International AIDS Society·Eileen Stillwaggon, Larry Sawers
Jun 13, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen A BerryUNKNOWN HIV Research Network
Nov 4, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Martin Ward Platt
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group
Jul 19, 2016·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team

❮ Previous
Next ❯

Citations

Jan 8, 2020·Sexually Transmitted Infections·Alessandra Anna SeccoUNKNOWN DC Cohort Executive Committee
Aug 25, 2019·Sexually Transmitted Infections·J Carlo HojillaDerek D Satre
Dec 10, 2020·AIDS Patient Care and STDs·Adi NoimanUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Aug 28, 2020·AIDS Research and Human Retroviruses·Stephanie ShiauDavid J Moore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.