Sexually transmitted infections and HIV RNA levels in blood and anogenital compartments among Thai men who have sex with men before and after antiretroviral therapy: implication for Treatment as Prevention programme

Journal of the International AIDS Society
Nittaya PhanuphakThai MSM/TG Test and Treat Study Group

Abstract

Sexually transmitted infections (STIs) are common among HIV-positive men who have sex with men (MSM). There have been concerns that undiagnosed and untreated STIs could undermine efforts to use antiretroviral therapy (ART) for prevention due to genital secretion infectiousness. We evaluated the correlation between STIs and HIV RNA in anogenital compartments among HIV-positive MSM before and after ART. MSM participants newly diagnosed with HIV were offered ART regardless of CD4 count during November 2012 to November 2015. Syphilis serology, oropharyngeal swab, rectal swab, urine collection for gonorrhoea and chlamydia nucleic acid amplification testing, and HIV RNA measurement in blood, semen and rectal samples were performed at baseline, 12 and 24 months thereafter. Of 143 HIV-positive MSM, 16.1% had syphilis, 23.1% had gonorrhoea and 32.8% had chlamydia at baseline. Participants with STIs at baseline had higher median HIV RNA levels in blood plasma (p = 0.053), seminal plasma (p = 0.01) and rectal secretions (p = 0.002) than those without STIs. Multivariate models identified HIV RNA 100,000 to 500,000 (OR 6.74, 95% CI 2.24 to 20.28, p = 0.001) and >500,000 (OR 9.39, 95% CI 1.08 to 81.72, p = 0.04) copies/mL in blood, CD4 count...Continue Reading

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Citations

Sep 8, 2019·AIDS Research and Therapy·Camilla MucciniNittaya Phanuphak
Jan 30, 2020·Current HIV Research·Poramed Winichakoon, Siripong Tongjai
Jan 10, 2021·The Journal of Sexual Medicine·Adrian PilatzThorsten Diemer
Jul 9, 2021·International Journal of STD & AIDS·Maganizo B ChagomeranaMyron Cohen

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Methods Mentioned

BETA
nucleic acid amplification

Clinical Trials Mentioned

NCT01869595

Software Mentioned

PARTNER
Stata

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