Sézary syndrome and mycosis fungoides: An overview, including the role of immunophenotyping.

Cytometry. Part B, Clinical Cytometry
Melissa P PulitzerJulia Almeida

Abstract

This review discusses the definition and major categories of cutaneous T-cell lymphoma, Sézary syndrome and mycosis fungoides, and the role of immunophenotyping in their diagnosis. The following key points are raised: (a) Sézary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7- and/or CD26- immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non-neoplastic T cells and other subtypes of mature T-cell neoplasm. (c) However, small subsets of normal and reactive T-cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.

References

Feb 13, 2001·The British Journal of Dermatology·M G BernengoM T Fierro
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Nov 19, 2005·Journal of Cutaneous Pathology·Günter BurgSean Whittaker
Jul 18, 2006·Journal of the American Academy of Dermatology·Emmilia HodakMeora Feinmesser
Aug 21, 2007·Journal of the American Academy of Dermatology·Shaheen OshtoryHoward J Meyerson
Nov 10, 2009·The American Journal of Surgical Pathology·James T EdingerSteven H Swerdlow
May 10, 2011·The American Journal of Dermatopathology·Chris H JokinenHarvey A Greisman
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elise A OlsenUNKNOWN Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer
Apr 13, 2012·The Journal of Investigative Dermatology·Christine L JonesTracey J Mitchell
Mar 20, 2014·The British Journal of Dermatology·J J ScarisbrickP Quaglino
Feb 15, 2016·Journal of the American Academy of Dermatology·Juliet F GibsonMichael Girardi
Jan 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charlotte HurabielleAnne Marie-Cardine
Aug 2, 2017·Blood·Marie RoelensHélène Moins-Teisserenc
Apr 1, 2016·Diagnostic Histopathology·Pooja VirmaniMelissa Pulitzer
Feb 25, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Julia J ScarisbrickMaarten H Vermeer
Feb 5, 2019·American Journal of Clinical Pathology·Natasha D NovikovDavid M Dorfman

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