SFN-SIQ, SFNSL and skin biopsy of 55 cases with small fibre involvement

The International Journal of Neuroscience
Bo SunXu-Sheng Huang

Abstract

Purpose/aim of the study: To date, there are no validated screening scales for small fibre neuropathy. This study investigated the small-fibre neuropathy and the symptom inventory questionnaire as well as the small fibre neuropathy screening list for small fibre neuropathy diagnosis. Fifty-five patients were divided into small fibre neuropathy and mixed fibre damage groups. Relevant scales, nerve conduction studies and skin biopsies were performed. Relationships between the intraepidermal nerve fibre density and different scales as well as the diagnostic and cut-off values (score at which Youden's index is largest) were determined. Compared with healthy Chinese participants, 20 patients were diagnosed with small fibre neuropathy. Intraepidermal nerve fibre density was moderately and highly correlated with the small fibre neuropathy-symptom inventory questionnaire and small fibre neuropathy screening list, respectively. The diagnostic values were moderate and high for the small fibre neuropathy-symptom inventory questionnaire (cut-off value = 5, sensitivity = 80%, specificity = 81.8%) and small fibre neuropathy screening list (cut-off value = 8, sensitivity = 94.1%, specificity = 90.9%), respectively. There were no significant d...Continue Reading

References

Oct 1, 1995·Neurology·B G McCarthyJ C McArthur
Apr 1, 1993·Journal of the Neurological Sciences·W R Kennedy, G Wendelschafer-Crabb
Aug 9, 2001·Muscle & Nerve·J R SingletonM B Bromberg
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·J W G MeijerT P Links
Jan 15, 2003·Neurology·C J SumnerM Polydefkis
May 12, 2004·Archives of Internal Medicine·A Gordon Smith, J Robinson Singleton
Nov 18, 2004·Journal of the Neurological Sciences·E HoitsmaC G Faber
Jul 9, 2008·Journal of the Neurological Sciences·A Gordon SmithJ Robinson Singleton
Oct 5, 2010·Respiratory Medicine·Elske HoitsmaMarjolein Drent
Nov 3, 2010·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaIngemar S J Merkies
Mar 14, 2013·Muscle & Nerve·Cecilia M ShikumaUNKNOWN SEARCH 014 Protocol Team
May 30, 2013·Muscle & Nerve·Mayienne BakkersIngemar S J Merkies
Apr 30, 2014·Practical Neurology·Andreas C ThemistocleousDavid L H Bennett
May 16, 2014·Journal of Clinical Neurology·Kristin SamuelssonRayomand Press
Apr 4, 2015·The American Journal of Case Reports·Lisa D Hobson-WebbPriya S Kishnani

❮ Previous
Next ❯

Citations

Apr 11, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Natalia Y BasantsovaYehuda Shoenfeld
Mar 7, 2020·Chinese Medical Journal·Bo SunXu-Sheng Huang
Feb 3, 2021·Annals of Clinical and Translational Neurology·Jing YangYuming Xu
Nov 24, 2020·Neurologic Clinics·Lawrence A Zeidman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.