Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes

Genes & Development
Benjamin AlbertDavid Shore

Abstract

The yeast Sfp1 protein regulates both cell division and growth but how it coordinates these processes is poorly understood. We demonstrate that Sfp1 directly controls genes required for ribosome production and many other growth-promoting processes. Remarkably, the complete set of Sfp1 target genes is revealed only by a combination of ChIP (chromatin immunoprecipitation) and ChEC (chromatin endogenous cleavage) methods, which uncover two promoter binding modes, one requiring a cofactor and the other a DNA-recognition motif. Glucose-regulated Sfp1 binding at cell cycle "START" genes suggests that Sfp1 controls cell size by coordinating expression of genes implicated in mass accumulation and cell division.

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Citations

Jul 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Christian A ShivelyRobi D Mitra
Jul 31, 2019·Cells·Emiliano Matos-Perdomo, Félix Machín
Oct 22, 2020·Nucleic Acids Research·Sevil ZencirBenjamin Albert
Oct 16, 2020·MSphere·Faiza TebbjiAdnane Sellam
Feb 16, 2021·Stem Cell Reviews and Reports·Hélia FernandesEugénia Carvalho
Aug 12, 2021·Microbial Biotechnology·Galal YahyaZuzana Storchova
Jul 10, 2021·Biochemical Society Transactions·David ShoreBenjamin Albert

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